STUDY OF THE CROSS-TALK BETWEEN THE SRC PROTO-ONCOGENE AND F-ACTIN DURING TUMOURAL TRANSFORMATION

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The role of actin cytoskeleton downstream of the Src oncogene in the earlier events of breast tumour progression

Publication . Tavares, Sandra Raquel de Oliveira; Janody, Florence

Tumorigenesis is a multistep process, by which cells acquire genetic and epigenetic alterations in oncogenes and tumour suppressor genes, which provide growth and/or survival advantage. Subsequent alterations may condemn these pre-malignant cells into malignant ones with invasive and metastatic abilities. Proto-oncogenes of the Src-family kinases have been linked to tumorigenesis and their over-expression and activation described in breast cancer. Increased Src activity has been associated with increased cell proliferation, survival, epithelialmesenchymal transition (EMT), migration, invasion and metastasis. Although Src is well-known to trigger cancer cell mobility, migration and invasion, through regulation of filamentous actin (F-actin), whether it also uses F-actin to promote proliferation and survival of tumour cells at pre-malignant stages remains unknown. Our lab has demonstrated that Src promotes apical F-actin accumulation in Drosophila epithelia. In turn, F-actin limits Src-induced apoptosis or tissue overgrowth.(...)

2016Tese de doutoramento

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Entidade financiadora

Fundação para a Ciência e a Tecnologia

Número da atribuição

SFRH/BD/51884/2012