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http://hdl.handle.net/10362/98893| Title: | Synthesis and antibacterial activity of ionic liquids and organic salts based on penicillin g and amoxicillin hydrolysate derivatives against resistant bacteria |
| Author: | Ferraz, Ricardo Silva, Dário Dias, Ana Rita Dias, Vitorino Santos, Miguel M. Pinheiro, Luís Prudêncio, Cristina Noronha, João Paulo Petrovski, Željko Branco, Luís C. |
| Keywords: | Active pharmaceutical ingredients-ionic liquids and organic salts (API-OSILs) Penicillin G and amoxicillin hydrolysate derivatives Resistant bacteria Sensitive bacteria Pharmaceutical Science |
| Issue Date: | Mar-2020 |
| Citation: | Ferraz, R., Silva, D., Dias, A. R., Dias, V., Santos, M. M., Pinheiro, L., Prudêncio, C., Noronha, J. P., Petrovski, Ž., & Branco, L. C. (2020). Synthesis and antibacterial activity of ionic liquids and organic salts based on penicillin g and amoxicillin hydrolysate derivatives against resistant bacteria. Pharmaceutics, 12(3), Article 221. https://doi.org/10.3390/pharmaceutics12030221 |
| Abstract: | The preparation and characterization of ionic liquids and organic salts (OSILs) that contain anionic penicillin G [secoPen] and amoxicillin [seco-Amx] hydrolysate derivatives and their in vitro antibacterial activity against sensitive and resistant Escherichia coli and Staphylococcus aureus strains is reported. Eleven hydrolyzed β-lactam-OSILs were obtained after precipitation in moderate-to-high yields via the neutralization of the basic ammonia buffer of antibiotics with different cation hydroxide salts. The obtained minimum inhibitory concentration (MIC) data of the prepared compounds showed a relative decrease of the inhibitory concentrations (RDIC) in the order of 100 in the case of [C2OHMIM][seco-Pen] against sensitive S. aureus ATCC25923 and, most strikingly, higher than 1000 with [C16Pyr][seco-Amx] against methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300. These outstanding in vitro results showcase that a straightforward transformation of standard antibiotics into hydrolyzed organic salts can dramatically change the pharmaceutical activity of a drug, including giving rise to potent formulations of antibiotics against deadly bacteria strains. |
| Description: | Fundacao para a Ciencia e Tecnologia through projects (PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013) and PTDC/BTM-SAL/29786/2017, and one contract under Investigador FCT (L.C.B.). ZP thanks to Fundacao para a Ciencia e a Tecnologia, MCTES, for the Norma transitoria DL 57/2016 Program Contract. This work was also supported by the Associate Laboratory for Green Chemistry, which is financed by national funds from FCT/MEC, UIDB/50006/2020 and co‐financed by the ERDF under the PT2020 Partnership Agreement (POCI‐01‐ 0145‐FEDER‐007265). The authors also thank Solchemar company for support. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/98893 |
| DOI: | https://doi.org/10.3390/pharmaceutics12030221 |
| ISSN: | 1999-4923 |
| Appears in Collections: | FCT: DQ - Artigos em revista internacional com arbitragem científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| pharmaceutics_12_00221_v2.pdf | 5,38 MB | Adobe PDF | View/Open |
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