Please use this identifier to cite or link to this item:
http://hdl.handle.net/10362/97244| Title: | Tofacitinib synthesis – An asymmetric challenge |
| Author: | Carvalho, Luísa C. R. Lourenço, Ana Ferreira, Luísa Maria Branco, Paula Sério |
| Keywords: | Asymmetric synthesis Chiral resolution Nitrogen heterocycles Piperidine rings Tofacitinib Physical and Theoretical Chemistry Organic Chemistry |
| Issue Date: | 2019 |
| Citation: | Carvalho, L. C. R., Lourenço, A., Ferreira, L. M., & Branco, P. S. (2019). Tofacitinib synthesis – An asymmetric challenge. European Journal of Organic Chemistry, 2019(4), 615-624. https://doi.org/10.1002/ejoc.201801180 |
| Abstract: | Tofacitinib is a Janus activated kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis and active psoriatic arthritis. Its synthesis normally involves long synthetic sequences due to the chirality associated to the piperidine ring. This review is a comprehensive analysis of the different synthetic methods used to prepare this active pharmaceutical ingredient (API), covering the related journal and patent literature. |
| Description: | co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265). The authors would like to thank Hovione FarmaCiencia SA for financial support. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/97244 |
| DOI: | https://doi.org/10.1002/ejoc.201801180 |
| ISSN: | 1434-193X |
| Appears in Collections: | FCT: DQ - Artigos em revista internacional com arbitragem científica |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| carvalho2018.pdf | 2,46 MB | Adobe PDF | View/Open |
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