Tofacitinib synthesis – An asymmetric challenge

Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/97244

Título:	Tofacitinib synthesis – An asymmetric challenge
Autor:	Carvalho, Luísa C. R. Lourenço, Ana Ferreira, Luísa Maria Branco, Paula Sério
Palavras-chave:	Asymmetric synthesis Chiral resolution Nitrogen heterocycles Piperidine rings Tofacitinib Physical and Theoretical Chemistry Organic Chemistry
Data:	2019
Citação:	Carvalho, L. C. R., Lourenço, A., Ferreira, L. M., & Branco, P. S. (2019). Tofacitinib synthesis – An asymmetric challenge. European Journal of Organic Chemistry, 2019(4), 615-624. https://doi.org/10.1002/ejoc.201801180
Resumo:	Tofacitinib is a Janus activated kinase (JAK) inhibitor approved for the treatment of rheumatoid arthritis and active psoriatic arthritis. Its synthesis normally involves long synthetic sequences due to the chirality associated to the piperidine ring. This review is a comprehensive analysis of the different synthetic methods used to prepare this active pharmaceutical ingredient (API), covering the related journal and patent literature.
Descrição:	co-financed by the ERDF under the PT2020 Partnership Agreement (POCI-01-0145-FEDER-007265). The authors would like to thank Hovione FarmaCiencia SA for financial support.
Peer review:	yes
URI:	http://hdl.handle.net/10362/97244
DOI:	https://doi.org/10.1002/ejoc.201801180
ISSN:	1434-193X
Aparece nas colecções:	FCT: DQ - Artigos em revista internacional com arbitragem científica

Ficheiros deste registo:

Ficheiro	Descrição	Tamanho	Formato
carvalho2018.pdf		2,46 MB	Adobe PDF	Ver/Abrir