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Study of the QrcABCD membrane complex involved in energy conservation in gut anaerobes
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| 4.19 MB | Adobe PDF |
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Resumo(s)
"The human gut microbiome has been studied for several decades, and changes in its
composition affect human physiology and may trigger health disorders. Sulfate-reducing
prokaryotes (SRP) are members of this diverse microbiota and are implicated in inflammatory
bowel diseases (IBD) and in colorectal cancer due to sulfide toxicity, which is released as the
main product of their metabolism. In the gut, one of the main electron sources for microbial
respiration is hydrogen and SRP can use it to respire sulfate producing sulfide. The QrcABCD is
an electrogenic respiratory complex, present in the inner membrane, that is essential to link the
periplasmic oxidation of hydrogen to sulfate metabolism inside the cell.(...)"
Descrição
Palavras-chave
Sulfate-reducing prokaryotes Phenotypic characterizations Dissimilatory sulfate reduction Energy conservation mechanisms Respiratory membrane complexes