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Chagas Disease
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Orientador(es)
Resumo(s)
Chagas disease (CD) is a vector-borne Neglected Zoonotic Disease (NZD) caused by a flagellate protozoan, Trypanosoma cruzi, that affects various mammalian species across America, including humans and domestic animals. However, due to an increase in population movements and new routes of transmission, T. cruzi infection is presently considered a worldwide health concern, no longer restricted to endemic countries. Dogs play a major role in the domestic cycle by acting very efficiently as reservoirs and allowing the perpetuation of parasite transmission in endemic areas. Despite the significant progress made in recent years, still there is no vaccine against human and animal disease, there are few drugs available for the treatment of human CD, and there is no standard protocol for the treatment of canine CD. In this review, we highlight human and canine Chagas Disease in its different dimensions and interconnections. Dogs, which are considered to be the most important peridomestic reservoir and sentinel for the transmission of T. cruzi infection in a community, develop CD that is clinically similar to human CD. Therefore, an integrative approach, based on the One Health concept, bringing together the advances in genomics, immunology, and epidemiology can lead to the effective development of vaccines, new treatments, and innovative control strategies to tackle CD.
Descrição
Funding Information: This study was supported by FCT\u2014Foundation for Science and Technology, I.P., through research grants EXPL/CVT-CVT/0175/2021 (DOI 10.54499/EXPL/CVT-CVT/0175/2021) and PTDC/CVT-CVT/0228/2020 (DOI 10.54499/PTDC/CVT-CVT/0228/2020) and by national funds within the scope of Centro de Investiga\u00E7\u00E3o Interdisciplinar em Sanidade Animal (CIISA, UIDB/00276/2020), Al4AnimalS (LA/P/0059/2020), Global Health and Tropical Medicine (GHTM, UID/04413/2020) and LA-REAL (LA/P/0117/2020). Joana Palma Marques and Marta Monteiro have Ph.D. scholarship references 2021.05579BD and UI/BD/152819/2022, respectively. A. Rodrigues awards a CEECIND/CP1725/CT0023 (10.54499/2022.00499.CEECIND/CP1725/CT0023). Publisher Copyright: © 2024 by the authors.
Palavras-chave
Chagas disease clinical signs dogs medical advances reservoir Trypanosoma cruzi vaccines zoonotic infection Infectious Diseases Parasitology General Veterinary SDG 3 - Good Health and Well-being