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http://hdl.handle.net/10362/150333| Title: | Synthesis of Bis(3-indolyl)methanes Mediated by Potassium tert-Butoxide |
| Author: | Santos, A. Sofia Ferro, Rita D. Viduedo, Nuno Maia, Luísa B. Silva, Artur M. S. Marques, M. Manuel B. |
| Keywords: | bis(indolyl)methanes indole tBuOK radicals benzylalcohols Chemistry(all) |
| Issue Date: | Jan-2023 |
| Abstract: | The indole moiety is an important N-heterocycle found in natural products, and a key structural component of many value-added chemicals including pharmaceuticals. In particular, bis(3-indolyl)methanes (BIMs) are an important subgroup of indoles, composed of two indole units. Herein, we report the development of a simple method to access BIMs derivatives in yields of up to 77 % by exploiting a tBuOK-mediated coupling reaction of indoles and benzyl alcohols. |
| Description: | The National NMR Facility is supported by FCT, ROTEIRO/0031/2013-PINFRA/22161/2016, co-financed by FEDER through COMPETE2020, POCI, and PORLandFCT through PIDDAC) and CERMAX(022162). |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/150333 |
| DOI: | https://doi.org/10.1002/open.202200265 |
| ISSN: | 2191-1363 |
| Appears in Collections: | Home collection (FCT) |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Synthesis_of_Bis_3_indolyl_methanes_Mediated_by_Potassium_tert_Butoxide.pdf | 4,35 MB | Adobe PDF | View/Open |
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