Utilize este identificador para referenciar este registo:
http://hdl.handle.net/10362/149555| Título: | The endolysosomal system and proteostasis |
| Autor: | Winckler, Bettina Faundez, Victor Maday, Sandra Cai, Qian Almeida C, Guimas Zhang, Huaye |
| Palavras-chave: | Autophagy Endosomes Lysosome Membrane trafficking Neurons Polarity Neuroscience(all) |
| Data: | 31-Out-2018 |
| Resumo: | How do neurons adapt their endolysosomal system to address the particular challenge of membrane transport across their elaborate cellular landscape and to maintain proteostasis for the lifetime of the organism? Here we review recent findings that address this central question. We discuss the cellular and molecular mechanisms of endolysosomal trafficking and the autophagy pathway in neurons, as well as their role in neuronal development and degeneration. These studies highlight the importance of understanding the basic cell biology of endolysosomal trafficking and autophagy and their roles in the maintenance of proteostasis within the context of neurons, which will be critical for developing effective therapies for various neurodevelopmental and neurodegenerative disorders. |
| Descrição: | Funding Information: This work was supported by National Institutes of Health Grants NS081674 and NS083378 to B.W., AG060285 to V.F., NS089737 and NS102780 to Q.C., and NS089578 to H.Z. S.M. was supported by National Institutes of Health Grant NS082619, the McCabe Fund Fellow Award, the University of Pennsylvania Alzheimer’s Disease Core Center, the Intellectual and Developmental Disabilities Research Center at the Children’s Hospital of Philadelphia and the University of Pennsylvania, and the Philadelphia Foundation. C.G.A. was supported by Maratona da Saude Award H2020/JPND (JPCOFUND/0004/2015-NAB3) and iNOVA4Health (UID/Multi/04462/2013, Fundação para a Ciência e Tecnologia/Ministério da Educação e Ciência/PT2020). Funding Information: Received Aug. 1, 2018; revised Sept. 17, 2018; accepted Sept. 20, 2018. ThisworkwassupportedbyNationalInstitutesofHealthGrantsNS081674andNS083378toB.W.,AG060285to V.F., NS089737 and NS102780 to Q.C., and NS089578 to H.Z. S.M. was supported by National Institutes of Health Grant NS082619, the McCabe Fund Fellow Award, the University of Pennsylvania Alzheimer’s Disease Core Center, the Intellectual and Developmental Disabilities Research Center at the Children’s Hospital of Philadelphia and the University of Pennsylvania, and the Philadelphia Foundation. C.G.A. was supported by Maratona da Saude Award H2020/JPND (JPCOFUND/0004/2015-NAB3) and iNOVA4Health (UID/Multi/04462/2013, Fundac¸ão para a Ciência e Tecnologia/Ministério da Educac¸ão e Ciência/PT2020). The authors declare no competing financial interests. Correspondence should be addressed to Dr. Huaye Zhang, Department of Neuroscience and Cell Biology, Rutgers Robert Wood Johnson Medical School, 675 Hoes Lane West, Piscataway, NJ 08854. E-mail: huaye.zhang@rutgers.edu. DOI:10.1523/JNEUROSCI.1665-18.2018 Copyright © 2018 the authors 0270-6474/18/389364-11$15.00/0 Publisher Copyright: © 2018 the authors. Copyright: Copyright 2018 Elsevier B.V., All rights reserved. |
| Peer review: | yes |
| URI: | http://hdl.handle.net/10362/149555 |
| DOI: | https://doi.org/10.1523/JNEUROSCI.1665-18.2018 |
| ISSN: | 0270-6474 |
| Aparece nas colecções: | NMS: CEDOC - Artigos em revista internacional com arbitragem científica |
Ficheiros deste registo:
| Ficheiro | Descrição | Tamanho | Formato | |
|---|---|---|---|---|
| 9364.full.pdf | 608,05 kB | Adobe PDF | Ver/Abrir |
Todos os registos no repositório estão protegidos por leis de copyright, com todos os direitos reservados.
