Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/148589
Título: Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Cabo Verde Medicinal Plants
Autor: P. Essoh, Anyse
Liberal, Ângela
Fernandes, Ângela
Dias, Maria Inês
Pereira, Carla
Mandim, Filipa
Moldão-Martins, Margarida
Cravo, Pedro
Duarte, Maria Paula
Moura, Mónica
Romeiras, Maria M.
Barros, Lillian
Palavras-chave: bioactive properties
Cabo Verde
endemic medicinal plants
traditional medicine
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Molecular Medicine
Pharmaceutical Science
Drug Discovery
SDG 3 - Good Health and Well-being
SDG 12 - Responsible Consumption and Production
Data: Set-2022
Resumo: The use of medicinal plants in a variety of health conditions remains essential for the discovery of new treatments. The present study aimed to investigate the bioactive properties of three native plants from Cabo Verde Islands, namely Artemisia gorgonum Webb, Sideroxylon marginatum (Decne. ex Webb) Cout., and Tamarix senegalensis DC., contributing to the characterization of less-known medicinal plants and their potential benefits for human health. Known compounds, such as kaempferol, quercetin, caffeyolquinic, and apigenin derivatives, among others, were detected in the plant species under study. Overall, all species demonstrated good antioxidant capacity, especially the ethanolic extracts of A. gorgonum (EC50 = 0.149 mg/mL) in TBARS assay. Moreover, the ethanolic extracts of the studied plants showed cytotoxic properties against tumor cells, and again the A. gorgonum extract proved to be the most effective in inhibiting tumor growth, mainly in the CaCO2 (GI50 = 17.3 μg/mL) and AGS (GI50 = 18.2 μg/mL) cell lines. Only the ethanolic extracts of T. senegalensis and S. marginatum demonstrated anti-inflammatory activity, albeit weak (EC50 = 35 and 43 μg/mL, respectively). The present study contributed to increased knowledge about the bioactive properties of these plants commonly used in traditional medicine, some of which was discussed for the first time, opening new perspectives for their use in a wider range of health conditions, especially in African countries, where access to modern health care is more limited.
Descrição: Funding Information: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); National funding by FCT, P.I., through the individual scientific employment program contract for L. Barros, A. Fernandes, M.I. Dias and C. Pereira. This research was funded by Fundação para a Ciência e a Tecnologia (FCT) and Aga Khan Development Network (AKDN) under the project CVAgrobiodiversity/333111699. Publisher Copyright: © 2022 by the authors.
Peer review: yes
URI: http://hdl.handle.net/10362/148589
DOI: https://doi.org/10.3390/ph15091162
ISSN: 1424-8247
Aparece nas colecções:Home collection (IHMT)

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