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http://hdl.handle.net/10362/130062| Title: | The role of Ubiquitin Specific Protease 7 on Latency Associated Nuclear Antigen DNA binding |
| Author: | Nunes, Gonçalo Pedro da Silva |
| Keywords: | Kaposi’s sarcoma herpesvirus Latency associated nuclear antigen Ubiquitin Specific Protease 7 LANA-USP7 complex Lana Binding Site DNA |
| Defense Date: | Sep-2018 |
| Publisher: | Universidade Nova de Lisboa. Instituto de Tecnologia Quimica e Biológica António Xavier |
| Abstract: | The implications of USP7 (Ubiquitin Specific Protease 7, deubiquitinating enzyme involved in several crucial molecular pathways) interactions with LANA (Latency Associated Nuclear Antigen protein, that facilitates the tethering of viral γ-Herpesvirus episomes into the host’s DNA and promotes its replication) has multiple health consequences, since USP7 is a protein that has an essential role it the regulation of many cellular functions, like the p53-mdm2 pathway, that regulates cellular apoptosis and prevents cancer. |
| Description: | Dissertation presented to obtain the Master degree in Biochemistry for Health |
| URI: | http://hdl.handle.net/10362/130062 |
| Appears in Collections: | ITQB: SV- MA Dissertations |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Nunes 2018 Final.pdf | 2,13 MB | Adobe PDF | View/Open |
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