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Publicação
Metabolic flux analysis of neural cell metabolism in primary cultures
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Resumo(s)
Brain energy metabolism results from a complex group of pathways and trafficking
mechanisms between all cellular components in the brain, and importantly provides the
energy for sustaining most brain functions. In recent decades, 13C nuclear magnetic
resonance (NMR) spectroscopy and metabolic modelling tools allowed quantifying the
main cerebral metabolic fluxes in vitro and in vivo. These investigations contributed
significantly to elucidate neuro-glial metabolic interactions, cerebral metabolic
compartmentation and the individual contribution of neurons and astrocytes to brain
energetics. However, many issues in this field remain unclear and/or under debate.
Descrição
Dissertation presented to obtain the Ph.D degree in Biochemistry, Neuroscience
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Editora
Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica