Please use this identifier to cite or link to this item: http://hdl.handle.net/10362/6849
Title: Metabolic flux analysis of neural cell metabolism in primary cultures
Author: Amaral, Ana Isabel Porém
Advisor: Alves, Paula M.
Sonnewald, Ursula
Defense Date: Oct-2011
Publisher: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Abstract: Brain energy metabolism results from a complex group of pathways and trafficking mechanisms between all cellular components in the brain, and importantly provides the energy for sustaining most brain functions. In recent decades, 13C nuclear magnetic resonance (NMR) spectroscopy and metabolic modelling tools allowed quantifying the main cerebral metabolic fluxes in vitro and in vivo. These investigations contributed significantly to elucidate neuro-glial metabolic interactions, cerebral metabolic compartmentation and the individual contribution of neurons and astrocytes to brain energetics. However, many issues in this field remain unclear and/or under debate.
Description: Dissertation presented to obtain the Ph.D degree in Biochemistry, Neuroscience
URI: http://hdl.handle.net/10362/6849
Appears in Collections:ITQB: CBL - PhD Theses

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