Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/6849
Título: Metabolic flux analysis of neural cell metabolism in primary cultures
Autor: Amaral, Ana Isabel Porém
Orientador: Alves, Paula M.
Sonnewald, Ursula
Data de Defesa: Out-2011
Editora: Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica
Resumo: Brain energy metabolism results from a complex group of pathways and trafficking mechanisms between all cellular components in the brain, and importantly provides the energy for sustaining most brain functions. In recent decades, 13C nuclear magnetic resonance (NMR) spectroscopy and metabolic modelling tools allowed quantifying the main cerebral metabolic fluxes in vitro and in vivo. These investigations contributed significantly to elucidate neuro-glial metabolic interactions, cerebral metabolic compartmentation and the individual contribution of neurons and astrocytes to brain energetics. However, many issues in this field remain unclear and/or under debate.
Descrição: Dissertation presented to obtain the Ph.D degree in Biochemistry, Neuroscience
URI: http://hdl.handle.net/10362/6849
Aparece nas colecções:ITQB: CBL - PhD Theses

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