Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/45775
Título: The GO-DACT protocol
Autor: Vieira de-Sousa, Elsa
Canhão, H.
Alves, P.
Rodrigues, A. M.
Teixeira, F.
Tavares-Costa, J.
Bernardo, A.
Pimenta, S.
Pimentel-Santos, F.
Gomes, J. L.
Aguiar, R.
Videira, T.
Pinto, P.
Catita, C.
Santos, H.
Sequeira, G.
Ribeiro, C.
Teixeira, L.
Ávila-Ribeiro, P.
Martins, F. M.
Ribeiro, R. M.
Fonseca, J. E.
Palavras-chave: Clinical trial
Dactylitis
Psoriatic arthritis
Treatment algorithm
Rheumatology
Data: Abr-2018
Resumo: The GO-DACT is an investigator-initiated, multicentric randomized placebo-controlled double-blinded trial, that assesses dactylitis as primary endpoint. Psoriatic arthritis patients naïve to methotrexate and biologic disease modifying anti-rheumatic drugs, with at least one active dactylitis, were assigned to golimumab in combination with methotrexate or placebo in combination with methotrexate, for 24 weeks. Both clinical (dactylitis severity score and the Leeds dactylitis index) and imaging (high resolution magnetic resonance imaging), among others, were assessed as outcomes. The main objective of GO-DACT is to provide evidence to improve the treatment algorithm and care of psoria - tic arthritis patients with active dactylitis. In this manuscript we describe the GO-DACT protocol and general concepts of the methodology of this trial.
Peer review: yes
URI: http://www.scopus.com/inward/record.url?scp=85051034547&partnerID=8YFLogxK
http://www.actareumatologica.pt/archive_detail.php?id=219
ISSN: 0303-464X
Aparece nas colecções:NMS-FCM: CEDOC - Artigos em revista nacional com arbitragem científica



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