Pre-Clinical Evaluation of Targeted Therapies Using 3D Cell Models of Breast Cancer

Abstract

"Breast cancer (BC) is the most frequent malignancy and the deadliest cancer death in women. It is a heterogeneous disease characterized by high variability in tumor morphology, molecular characteristics, and clinical response. Development of targeted therapies has revolutionized cancer treatment; however, these therapies are associated with increased resistance. Development of novel therapies often fails due to lack of representation of the tumor microenvironment (TME), revealing the need for recapitulative models.(...)"