Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/182902
Título: Hemodynamic effect of outpatient levosimendan infusion assessed daily using the CardioMEMS™ invasive remote monitoring system
Autor: Teixeira, Ana Rita
Barbas de Albuquerque, Francisco
Pereira-da-Silva, Tiago
Gonçalves, António Valentim
Ilhão Moreira, Rita
Timóteo, Ana Teresa
Alves, João
Barquinha, Sofia
Mata, Rita
Dias, Mariline
Cacela, Duarte
Cruz Ferreira, Rui
Palavras-chave: Cardiac output
CardioMEMS™
Heart failure
Levosimendan
Pulmonary artery pressure
Cardiology and Cardiovascular Medicine
Data: Mai-2025
Resumo: Introduction and Objectives: Levosimendan infusion in the outpatient setting improves the clinical status of heart failure (HF) patients, although its hemodynamic effects are not entirely known. Remote monitoring using the CardioMEMS™ system enables daily assessment of pulmonary artery pressure (PAP) and estimation of cardiac output (CO). We aimed to assess the hemodynamic effects of outpatient levosimendan infusion using CardioMEMS™. Methods: All patients admitted for 6-hour levosimendan infusion (performed every 14 days) and using the CardioMEMS™ remote monitoring system were included in a prospective single-center registry. Clinical and laboratory data were recorded. Systolic, diastolic, and mean PAP, heart rate, CO, and stroke volume (SV) were assessed daily. Results: A total of 25 sessions were performed in three patients. There were no adverse events or significant therapy adjustments. There was a significant reduction in diastolic PAP the day after levosimendan infusion compared to baseline (day prior to infusion) (24.1±4.1 mmHg vs. 21.6±2.9 mmHg, p=0.006). Thereafter, diastolic PAP stabilized and remained significantly lower than baseline up to day 10. There were no significant differences in systolic PAP, mean PAP, heart rate, CO, or SV at any timepoint analyzed, although there was a nonsignificant increase in CO with a peak at day 6. Conclusion: Outpatient levosimendan infusion was associated with an early reduction in diastolic PAP, which was maintained for 10 days. The CardioMEMS™ system may enable a better understanding of outpatient hemodynamics in advanced HF. To our knowledge, there are no published data on this subject.
Descrição: Publisher Copyright: © 2025 Sociedade Portuguesa de Cardiologia
Peer review: yes
URI: http://hdl.handle.net/10362/182902
DOI: https://doi.org/10.1016/j.repc.2024.11.014
ISSN: 0870-2551
Aparece nas colecções:NMS - Artigos em revista nacional com arbitragem científica

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