Towards the establishment of a reference method for Mycobacterium avium drug susceptibility testing

Abstract

"Mycobacterium avium is the most common non-tuberculous mycobacteria (NTM) associated with human infections. Treatment of M. avium disease is challenging, with microbiological eradication typically requiring a multidrug antibacterial regimen over a prolonged period. This scenario worsens as no standardized drug susceptibility testing guidelines are available. This work aimed to evaluate the provisional European Committee for Susceptibility Testing (EUCAST) reference protocol for minimum inhibitory (MIC) determination of slow growing NTM, correlate it with established molecular determinants and examine its usefulness for testing new drugs.(...)"