Utilize este identificador para referenciar este registo: http://hdl.handle.net/10362/173919
Título: AFTER-CA
Autor: Ferreira, Mónica
Silva Cunha, Pedro
Felix, Ana Clara
Fonseca, Helena
Oliveira, Mario
Laranjo, Sergio
Rocha, Isabel
Palavras-chave: atrial fibrillation
autonomic function
baroreflex sensitivity
catheter ablation
cryoablation
heart rate variability
pulmonary vein isolation
quality of life
Medicine(all)
Data: Out-2024
Resumo: Background: Catheter ablation (CA) is a well-established treatment for atrial fibrillation (AF). However, its effects on autonomic function and underlying mechanisms remain poorly understood. This study investigated autonomic and haemodynamic changes following CA and explored their potential implications for patient outcomes. Methods: Seventy-eight patients with AF underwent CA and were followed up at one, three, and six months. Autonomic function was assessed using a combination of head-up tilt (HUT), handgrip (HG), and deep breathing (DB) manoeuvres along with baroreflex sensitivity (BRS) and baroreflex effectiveness index (BEI) evaluation. Heart rate (HR), blood pressure (BP), and their variability were measured at each time point. Results: Significant autonomic alterations were observed after ablation, particularly at one month, with reductions in parasympathetic tone and baroreflex function. These changes gradually normalised by six months. Both pulmonary vein isolation (PVI) and cryoablation (CryO) had similar effects on autonomic regulation. Improvements in quality of life, measured by the AFEQT scores, were consistent with these physiological changes. Conclusions: CA for AF induces significant time-dependent autonomic and haemodynamic changes with recovery over six months. These findings underscore the need for ongoing monitoring and personalised post-ablation management. Further research is required to explore the mechanisms driving these alterations and their long-term impacts on patient outcomes.
Descrição: Publisher Copyright: © 2024 by the authors.
Peer review: yes
URI: http://hdl.handle.net/10362/173919
DOI: https://doi.org/10.3390/jcm13195796
ISSN: 2077-0383
Aparece nas colecções:NMS: CHRC - Artigos em revista nacional com arbitragem científica

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