Structure and Dynamics of Pathogenic Scaffold Proteins

Hernandez, Guillem

http://hdl.handle.net/10362/163109

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Autores

Hernandez, Guillem

Resumo(s)

"Pathogens have evolved sophisticated mechanisms to control the host by hijacking and redirecting cellular processes. In this context, pathogens encode intrinsically disordered (ID) proteins (IDP) and/or proteins containing ID regions (IDR) that, once insid e host cells, employ their inherent flexibility/plasticity to mimic host protein interaction patterns to redirect the host immune responses and metabolism to induce beneficial conditions for the pathogen.(...)"

Palavras-chave

The thesis herein focuses on two examples of biologically relevant ID scaffold proteins (i.e., disordered effectors) involved in infections without any known (EHEC), the Translocated intimin receptor

URI

http://hdl.handle.net/10362/163109

Editora

Instituto de Tecnologia Química e Biológica António Xavier. Universidade Nova de Lisboa.

Coleções

ITQB: DSB-PhD Theses

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