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Low-Molecular Weight Metabolites from Polyphenols as Effectors for Attenuating Neuroinflammation
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Orientador(es)
Resumo(s)
Age-associated pathophysiological changes such as neurodegenerative diseases are multifactorial conditions with increasing incidence and no existing cure. The possibility of altering the progression and development of these multifactorial diseases through diet is an attractive approach with increasing supporting data. Epidemiological and clinical studies have highlighted the health potential of diets rich in fruits and vegetables. Such food sources are rich in (poly)phenols, natural compounds increasingly associated with health benefits, having the potential to prevent or retard the development of various diseases. However, absorption and the blood concentration of (poly)phenols is very low when compared with their corresponding (poly)phenolic metabolites. Therefore, these serum-bioavailable metabolites are much more promising candidates to overcome cellular barriers and reach target tissues, such as the brain. Bearing this in mind, it will be reviewed that the molecular mechanisms underlying (poly)phenolic metabolites effects, range from 0.1 to <50 μM and their role on neuroinflammation, a central hallmark in neurodegenerative diseases.
Descrição
Funding This work has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme under Grant Agreement No. 804229. The iNOVA4Health Research Unit (Grant LISBOA-01-0145-FEDER-007344), which is cofunded by Fundaca̧ o para a Cie ̃ ncia e Tecnologia (FCT)/Ministe ̂ rio da ́ Ciencia e do Ensino Superior, through national funds, and by ̂ FEDER under the PT2020 Partnership Agreement is acknowledged. The authors would like to acknowledge FCT for financial support of R.C. (Grant PD/BD/135492/2018).
Palavras-chave
brain flavonoid microbiota microglia neurodegenerative diseases General Chemistry General Agricultural and Biological Sciences