Osteopenia/osteoporosis and its association with sarcopenia: EpiFloripa Aging Study 2013/2014

Abstract

ABSTRACT - Objective: To verify the association between sarcopenia and osteopenia/osteoporosis in the older population from Florianópolis, Southern Brazil. Methods: A cross-sectional study with 598 older adults. The bone mineral density (BMD) was evaluated by total BMD, lumbar spine BMD (LS-BMD), femoral neck BMD (FN-BMD), and osteopenia/osteoporosis was defined when BMD (g/cm2) <–1 standard deviation of the sample mean. Sarcopenia was identified by the appendicular muscle mass index (AMMI), by sex, when AMMI < 7.26 kg/ m2 for men and < 5.5 kg/m2 for women. Results: Of the 598 subjects (63–93 years) in the sample, 65.4% were women. The proportion of altered BMD was 52.1% for total BMD, 62.5% for LS-BMD, and 70.9% for FN-BMD in women, while for men, altered BMD proportion was 29.3% for total BMD, 24.5% for LS-BMD, and 64.9% for FN-BMD. After adjustments, sarcopenia was associated with increased odds of altered LSBMD (OR: 12.25; 95% CI: 3.66–40.96 and OR: 2.90; 95% CI: 1.30–6.48) and FN-BMD (OR: 5.59; 95% CI: 1.64–19.05 and OR: 7.95; 95% CI: 3.23–19.57), respectively for women and men. The association between sarcopenia and altered total BMD (OR: 11.08; 95% CI: 3.84–31.97) was observed only in women. Conclusion: The proportion of osteopenia/osteoporosis was higher in women. Sarcopenia was associated with osteopenia/ osteoporosis in the population from Florianópolis, except for total BMD in men.

RESUMO - Objetivo: Verificar a associação entre sarcopenia e osteopenia/ osteoporose em idosos de Florianópolis, Sul do Brasil. Métodos: Trata-se de estudo transversal com 598 idosos. A osteopenia/osteoporose foi identificada por meio da densidade mineral óssea (DMO) total, DMO coluna lombar (DMO-CL) e DMO colo do fêmur (DMO-CF), sendo considerada alterada quando DMO (g/cm2) <–1 desvio padrão da média da amostra. A sarcopenia foi identificada por meio do índice de massa muscular apendicular (IMMA, Kg/m2), de acordo com o sexo, quando IMMA < 7,26 kg/m2 para homens e < 5,5 kg/m2 para mulheres. Resultados: Dos 598 indivíduos (63 a 93 anos) da amostra, 65,4% eram mulheres. A prevalência de osteopenia/osteoporose foi 52,1% para DMO-total, 62,5% para DMO-CL e 70,9% para DMO-CF nas mulheres. Para os homens, a osteopenia/osteoporose foi de 29,3% para DMO total, 24,5% para DMOCL e 64,9% para DMO-CF. Após ajustes, a sarcopenia foi associada a maiores chances de DMO-CL alterada (OR: 12,25; IC 95%: 3,66–40,96 e OR: 2,90; IC 95%: 1,30–6,48) e DMO-CF alterada (OR: 5,59; IC 95%: 1,64–19,05 e OR: 7,95; IC 95%: 3,23–19,57), para mulheres e homens, respectivamente. A sarcopenia foi associada à DMO-total alterada (OR: 11,08; IC 95%: 3,84–31,97) apenas em mulheres. Conclusão: A prevalência de osteopenia/osteoporose foi maior entre as mulheres. Idosos sarcopênicos apresentam maiores chances de ter osteopenia/osteoporose, exceto para DMO total em homens.