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Boosting immunity against multiple myeloma

2021-03-02Recensão Acesso aberto
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dc.contributor.authorLopes, Raquel
dc.contributor.authorFerreira, Bruna Velosa
dc.contributor.authorCaetano, Joana
dc.contributor.authorBarahona, Filipa
dc.contributor.authorCarneiro, Emilie Arnault
dc.contributor.authorJoão, Cristina
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2021-04-23T22:57:11Z
dc.date.available2021-04-23T22:57:11Z
dc.date.issued2021-03-02
dc.descriptionFunding: This research was funded by Fundação para a Ciência e Tecnologia (FCT), PTDC/MECHEM/30315/2017 and UIDB/04443/2020
dc.description.abstractDespite the improvement of patient’s outcome obtained by the current use of immunomod-ulatory drugs, proteasome inhibitors or anti-CD38 monoclonal antibodies, multiple myeloma (MM) remains an incurable disease. More recently, the testing in clinical trials of novel drugs such as anti-BCMA CAR-T cells, antibody–drug conjugates or bispecific antibodies broadened the possibility of improving patients’ survival. However, thus far, these treatment strategies have not been able to steadily eliminate all malignant cells, and the aim has been to induce a long-term complete response with minimal residual disease (MRD)-negative status. In this sense, approaches that target not only myeloma cells but also the surrounding microenvironment are promising strategies to achieve a sustained MRD negativity with prolonged survival. This review provides an overview of current and future strategies used for immunomodulation of MM focusing on the impact on bone marrow (BM) immunome.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent21
dc.format.extent1405295
dc.identifier.doi10.3390/cancers13061221
dc.identifier.issn2072-6694
dc.identifier.otherPURE: 29161605
dc.identifier.otherPURE UUID: 4195fb97-6692-4e64-9f14-b6de77d32a4c
dc.identifier.otherScopus: 85103360225
dc.identifier.otherPubMed: 33799565
dc.identifier.otherWOS: 000634340400001
dc.identifier.urihttp://hdl.handle.net/10362/116085
dc.identifier.urlhttps://www.scopus.com/pages/publications/85103360225
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBone marrow immune microenvironment
dc.subjectImmunotherapy
dc.subjectMultiple myeloma
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleBoosting immunity against multiple myelomaen
dc.typereview
degois.publication.firstPage1
degois.publication.issue6
degois.publication.lastPage21
degois.publication.titleCancers
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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