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Single cell analysis of toxinogenesis by vegetative and sporulating cells in the enteric pathogen Clostridioides difficile
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Resumo(s)
"Clostridium difficile, recently re-classified as Clostridioides
difficile, is a strict anaerobe, with the ability to form spores. C. difficile
is also a major nosocomial enteric pathogen worldwide and the cause of
severe gastrointestinal conditions that can lead to death. The oxygenresistant
spores allow host-host transmission, but also persistence of
the organism in the host and the environment, being linked to disease
recurrence. The last two decades have witnessed the emergence of
epidemic strains that increased the incidence of C. difficile infection
(CDI) associated with more severe symptoms and high recurrence
rates.(...)"
Descrição
Palavras-chave
toxinogenesis Clostridioides difficile