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A meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European children

2025-12Artigo científico Acesso aberto
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dc.contributor.authorLlauradó-Pont, Joana
dc.contributor.authorStratakis, Nikos
dc.contributor.authorFiorito, Giovanni
dc.contributor.authorHandakas, Evangelos
dc.contributor.authorNeumann, Alexander
dc.contributor.authorBarros, Henrique
dc.contributor.authorBrantsæter, Anne Lise
dc.contributor.authorChang, Kiara
dc.contributor.authorChatzi, Leda
dc.contributor.authorFelix, Janine F.
dc.contributor.authorGrazuleviciene, Regina
dc.contributor.authorJaddoe, Vincent W.V.
dc.contributor.authorKarachaliou, Marianna
dc.contributor.authorLecorguillé, Marion
dc.contributor.authorLopes, Carla
dc.contributor.authorMillett, Christopher
dc.contributor.authorMcEachan, Rosemary R.C.
dc.contributor.authorPapadopoulou, Eleni
dc.contributor.authorSlama, Remy
dc.contributor.authorVamos, Eszter P.
dc.contributor.authorVineis, Paolo
dc.contributor.authorVrijheid, Martine
dc.contributor.authorWright, John
dc.contributor.authorVoortman, Trudy
dc.contributor.authorBustamante, Mariona
dc.contributor.authorRobinson, Oliver
dc.contributor.authorLassale, Camille
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2025-06-05T21:20:36Z
dc.date.available2025-06-05T21:20:36Z
dc.date.issued2025-12
dc.descriptionFunding Information: We are grateful to participants in all cohorts included in the four studies (HELIX, Generation XXI, ALSPAC and Generation R) across countries who have generously given their time and collaborated in the studies. The HELIX cohort received funding from the European Community\u2019s Seventh Framework Programme (FP7/2007\u20132013) [grant number 308333]. Joana Llaurad\u00F3-Pont has received support from the European Union\u2014NextGenerationEU and the Spanish government, under the Investigo Programme (grant ID: 2022 INV-1 00046). Camille Lassale is supported by a Ramon y Cajal Fellowship RYC2020-029599 funded by MICIU/AEI/ https://doi.org/10.13039/501100011033 and the European Social Fund 'Invest in your future'. Nikos Stratakis has been supported from the European Union\u2019s Horizon Europe research and innovation programme under the Marie Sk\u0142odowska-Curie Actions (MSCA) Postdoctoral Fellowships (grant ID: 101059245), from the Ministry of Science and Innovation and State Research Agency through the 'Centro de Excelencia Severo Ochoa 2019\u20132023' Program (CEX2018-000806-S) and by a Juan de la Cierva-Incorporaci\u00F3n fellowship (IJC2020-043630-I) financed by Ministerio de Ciencia e Innovaci\u00F3n (MCIN)/Agencia Estatal de Investigaci\u00F3n (AEI)/ https://doi.org/10.13039/501100011033 and the European Union 'NextGenerationEU/PRTR'. Oliver Robinson was supported by a UKRI Future Leaders Fellowship (MR/S03532X/1). This work received funding from the European Union\u2019s Horizon 2020 research and innovation programme (774548, STOP; 874739, LongITools; 874583, EUCAN-Connect) and from the European Joint Programming Initiative 'A Healthy Diet for a Healthy Life' (JPI HDHL, NutriPROGRAM project, ZonMw the Netherlands no.529051022 and PREcisE project ZonMw the Netherlands no.529051023). Details of funding for each study and for contributions of individual studies can be found in Supplementary material S3 . No funders listed here or in Supplementary material S3 influenced the study aim, design, analysis or interpretation of results. The results expressed here are those of the authors and not necessarily any listed funder. Publisher Copyright: © The Author(s) 2024.
dc.description.abstractBackground/objective: There is limited knowledge on how diet affects the epigenome of children. Ultra-processed food (UPF) consumption is emerging as an important factor impacting health, but mechanisms need to be uncovered. We therefore aimed to assess the association between UPF consumption and DNA methylation in children. Methods: We conducted a meta-analysis of epigenome-wide association studies (EWAS) from a total of 3152 children aged 5–11 years from four European studies (HELIX, Generation XXI, ALSPAC, and Generation R). UPF consumption was defined applying the Nova food classification system (group 4), and DNA methylation was measured in blood with Illumina Infinium Methylation arrays. Associations were estimated within each cohort using robust linear regression models, adjusting for relevant covariates, followed by a meta-analysis of the resulting EWAS estimates. Results: Although no CpG was significant at FDR level, we found suggestive associations (p-value < 10–5) between UPF consumption and methylation at seven CpG sites. Three of them, cg00339913 (PHYHIP), cg03041696 (intergenic), and cg03999434 (intergenic), were negatively associated, whereas the other four, cg14665028 (NHEJ1), cg18968409 (intergenic), cg24730307 (intergenic), and cg09709951 (ATF7), were positively associated with UPF intake. These CpGs have been previously associated with health outcomes such as carcinomas, and the related genes are mainly involved in pathways related to thyroid hormones and liver function. Conclusion: We only found suggestive changes in methylation at 7 CpGs associated with UPF intake in a large EWAS among children: although this shows a potential impact of UPF intake on DNAm, this might not be a key mechanism underlying the health effects of UPFs in children. There is a need for more detailed dietary assessment in children studies and of intervention studies to assess potential epigenetic changes linked to a reduction in UPF in the diet.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1512054
dc.identifier.doi10.1186/s13148-024-01782-z
dc.identifier.issn1868-7075
dc.identifier.otherPURE: 117978178
dc.identifier.otherPURE UUID: 54d23c3c-def3-456a-b64e-3f986170ab47
dc.identifier.otherScopus: 85214247681
dc.identifier.otherPubMed: 39773758
dc.identifier.otherPubMedCentral: PMC11706074
dc.identifier.otherWOS: 001392972400001
dc.identifier.urihttp://hdl.handle.net/10362/183937
dc.identifier.urlhttps://www.scopus.com/pages/publications/85214247681
dc.language.isoeng
dc.peerreviewedyes
dc.subjectChildren
dc.subjectDNA methylation
dc.subjectEpigenome-wide association study (EWAS)
dc.subjectNutrition
dc.subjectUltra-processed food (UPF)
dc.subjectMolecular Biology
dc.subjectGenetics
dc.subjectDevelopmental Biology
dc.subjectGenetics(clinical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleA meta-analysis of epigenome-wide association studies of ultra-processed food consumption with DNA methylation in European childrenen
dc.typejournal article
degois.publication.issue1
degois.publication.titleClinical Epigenetics
degois.publication.volume17
dspace.entity.typePublication
rcaap.rightsopenAccess

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