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Sociodemographic and clinical features related to hepatitis B virus infection among rejected blood donors in Luanda, Angola
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Resumo(s)
Background: Hepatitis B virus (HBV) remains a public health concern. Blood donors screened for HBV surface antigen (HBsAg) along with aspartate transaminase (AST)/alanine aminotransferase (ALT) could play a key in providing safe blood products. We investigated the features related to HBV infection among rejected blood donors in Luanda, Angola. Methods: This was a cross-sectional study conducted with 164 rejected donors. Donors were screened for HBsAg from March to May 2022. Overall, 63.4% tested positive for HBV. Results: The mean age of the HBV-positive (29.2 ± 8.02) was lower than the HBV-negative (33.9 ± 10.0) (p < 0.001). Donors between 20 and 40 years (odds ratio [OR]: 2.34, p = 0.045), females (OR: 1.40, p = 0.516), residents in urbanized areas (OR: 1.23, p = 0.530), low educational (OR: 1.54, p = 0.458), unemployed (OR: 1.65, p = 0.271), and unmarried (OR:1.41, p = 0.616) might be likely to contract HBV. AST/ALT ratio was higher in HBV-infected (2.07 ± 1.42) than in HBV-uninfected (1.90 ± 1.14). About 20% of HBV-positive were classified as having acute liver disease, while 80% with chronic liver disease, based on AST/ALT ratio. Age ranged from 20 to 40 years (OR: 1.97, p = 0.305), females (OR: 1.61, p = 0.557), donors from non-urbanized (OR: 1.69, p = 0.557), a low educational (OR: 1.64, p = 0.571), and unemployed donors (OR: 1.81, p = 0.289) were likely to develop chronic liver disease. Conclusions: Our findings indicated the failure of viral hepatitis control measures. Authorities should consider including HBV nucleic acid testing to ensure early identification of HBV in Angola.
Descrição
Funding Information: The authors are grateful to all study participants. Thanks to the research team of CISA/INIS and INS for the data collection, laboratory procedure, and technical/administrative support. The present project was financially supported by the Funda\u00E7\u00E3o Calouste Gulbenkian (FCG), under the ENVOLVE Ci\u00EAncia PALOP program that funded the HITOLA project (number 250466), AREF (AREF-312-CRUZ-F-C0931), Science and Technology Development Project (PDCT) within the scope of the MUTHIVAO project (Number 36 MESCTI/PDCT/2022), FCT MARVEL (PTDC/SAU-PUB/4018/2021), FCT GHTM-UID/04413/2020 and LA-REAL-LA/P/0117/2020. The funders had no role in study design; collection, analysis, and interpretation of data; writing of the report; the decision to submit the report for publication. Funding Information: The authors are grateful to all study participants. Thanks to the research team of CISA/INIS and INS for the data collection, laboratory procedure, and technical/administrative support. The present project was financially supported by the Funda\u00E7\u00E3o Calouste Gulbenkian (FCG), under the ENVOLVE Ci\u00EAncia PALOP program that funded the HITOLA project (number 250466), AREF (AREF\u2010312\u2010CRUZ\u2010F\u2010C0931), Science and Technology Development Project (PDCT) within the scope of the MUTHIVAO project (Number 36 MESCTI/PDCT/2022), FCT MARVEL (PTDC/SAU\u2010PUB/4018/2021), FCT GHTM\u2010UID/04413/2020 and LA\u2010REAL\u2010LA/P/0117/2020. The funders had no role in study design; collection, analysis, and interpretation of data; writing of the report; the decision to submit the report for publication. Publisher Copyright: © 2024 The Author(s). Health Science Reports published by Wiley Periodicals LLC.
Palavras-chave
Angola blood donors HBsAg HBV infection liver damage General Medicine SDG 3 - Good Health and Well-being