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Longitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patients

2020-03-24Artigo científico Acesso aberto
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dc.contributor.authorGradel, Kim Oren
dc.contributor.authorPóvoa, Pedro
dc.contributor.authorPovoa, Pedro
dc.contributor.authorGarvik, Olav Sivertsen
dc.contributor.authorVinholt, Pernille Just
dc.contributor.authorNielsen, Stig Lønberg
dc.contributor.authorJensen, Thøger Gorm
dc.contributor.authorChen, Ming
dc.contributor.authorDessau, Ram Benny
dc.contributor.authorMøller, Jens Kjølseth
dc.contributor.authorCoia, John Eugenio
dc.contributor.authorLjungdalh, Pernille Sanberg
dc.contributor.authorLassen, Annmarie Touborg
dc.contributor.authorFrederiksen, Henrik
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.pblBioMed Central (BMC)
dc.date.accessioned2020-04-06T22:33:44Z
dc.date.available2020-04-06T22:33:44Z
dc.date.issued2020-03-24
dc.description.abstractBACKGROUND: No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML). METHODS: We studied defined events in 818 adult patients with AML in relation to 60,209 CRP and PA measures. We investigated correlations between CRP and PA levels and daily CRP and PA levels in relation to AML diagnosis, AML relapse, or bacteraemia (all ±30 days), and death (─30-0 days). RESULTS: On the AML diagnosis date (D0), CRP levels increased with higher WHO performance score (PS), e.g. patients with PS 3/4 had 68.1 mg/L higher CRP compared to patients with PS 0, adjusted for relevant covariates. On D0, the PA level declined with increasing PS, e.g. PS 3/4 had 7.54 g/L lower adjusted PA compared to PS 0. CRP and PA levels were inversely correlated for the PA interval 25-55 g/L (R = - 0.51, p < 10-5), but not for ≤24 g/L (R = 0.01, p = 0.57). CRP increases and PA decreases were seen prior to bacteraemia and death, whereas no changes occurred up to AML diagnosis or relapse. CRP increases and PA decreases were also found frequently in individuals, unrelated to a pre-specified event. CONCLUSIONS: PA decrease is an important biomarker for imminent bacteraemia in adult patients with AML.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1
dc.format.extent1411311
dc.identifier.doi10.1186/s12885-020-06754-z
dc.identifier.issn1471-2407
dc.identifier.otherPURE: 17642057
dc.identifier.otherPURE UUID: cf370ed2-b560-4a96-936f-7f53ad7155b8
dc.identifier.otherScopus: 85082380857
dc.identifier.otherPubMed: 32209087
dc.identifier.urihttp://hdl.handle.net/10362/95784
dc.identifier.urlhttps://www.scopus.com/pages/publications/85082380857
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAcute myeloid leukaemia
dc.subjectC-reactive protein
dc.subjectInfection
dc.subjectInflammation
dc.subjectPlasma albumin
dc.subjectGenetics
dc.subjectOncology
dc.subjectCancer Research
dc.subjectSDG 3 - Good Health and Well-being
dc.titleLongitudinal trajectory patterns of plasma albumin and C-reactive protein levels around diagnosis, relapse, bacteraemia, and death of acute myeloid leukaemia patientsen
dc.typejournal article
degois.publication.issue1
degois.publication.titleBMC Cancer
degois.publication.volume20
dspace.entity.typePublication
person.familyNamePovoa
person.givenNamePedro
person.identifier.ciencia-id0C16-5CF9-9238
person.identifier.orcid0000-0002-7069-7304
person.identifier.scopus-author-id6602772147
rcaap.rightsopenAccess
relation.isAuthorOfPublication04ec38ba-be1e-46e5-8007-0e65a557d0f4
relation.isAuthorOfPublication.latestForDiscovery04ec38ba-be1e-46e5-8007-0e65a557d0f4

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