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Intestinal Alkaline Phosphatase

2022-03-30Recensão Acesso aberto
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dc.contributor.authorSantos, Gilberto Maia
dc.contributor.authorIsmael, Shámila
dc.contributor.authorMorais, Juliana
dc.contributor.authorAraújo, João R.
dc.contributor.authorFaria, Ana
dc.contributor.authorCalhau, Conceição
dc.contributor.authorCalhau, Conceição
dc.contributor.authorMarques, Cláudia
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionCentro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS)
dc.contributor.pblMDPI AG
dc.date.accessioned2022-04-27T22:44:56Z
dc.date.available2022-04-27T22:44:56Z
dc.date.issued2022-03-30
dc.descriptionFunding Information: This study was supported by ERDF through the operation POCI-01-0145-ERDF-007746 funded by Programa Operacional Competitividade e Internacionaliza??o?COMPETE2020 and by National Funds through FCT?Funda??o para a Ci?ncia e a Tecnologia within CINTESIS, R&D Unit (reference UID/IC/4255/2013) and (PTDC/BAA-AGR/7419/2020).
dc.description.abstractIntestinal alkaline phosphatase (IALP) has recently assumed a special relevance, being the subject of study in the prevention and treatment of certain diseases related to leaky gut. This brush border enzyme (ecto-enzyme) plays an important role in the maintenance of intestinal microbial homeostasis and intestinal barrier function through its ability to dephosphorylate lipopolysaccharide (LPS). This review addresses how IALP and intestinal barrier dysfunction may be implicated in the pathophysiology of specific diseases such as inflammatory bowel disease, necrotizing enterocolitis, and metabolic syndrome. The use of IALP as a possible biomarker to assess intestinal barrier function and strategies to modulate IALP activity are also discussed.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1480572
dc.identifier.doi10.3390/microorganisms10040746
dc.identifier.issn2076-2607
dc.identifier.otherPURE: 43328751
dc.identifier.otherPURE UUID: 3d16970c-0775-4219-938c-2c0e8c3a1af6
dc.identifier.otherScopus: 85127426722
dc.identifier.otherPubMed: 35456797
dc.identifier.otherWOS: 000786815200001
dc.identifier.urihttp://hdl.handle.net/10362/137066
dc.identifier.urlhttps://www.scopus.com/pages/publications/85127426722
dc.language.isoeng
dc.peerreviewedyes
dc.subjectinflammatory bowel disease
dc.subjectintestinal alkaline phosphatase
dc.subjectintestinal barrier function
dc.subjectlow-grade chronic inflammation
dc.subjectmetabolic dysfunction
dc.subjectnecrotizing enterocolitis
dc.subjectobesity
dc.subjectMicrobiology
dc.subjectMicrobiology (medical)
dc.subjectVirology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIntestinal Alkaline Phosphataseen
dc.title.subtitleA Review of This Enzyme Role in the Intestinal Barrier Functionen
dc.typereview
degois.publication.issue4
degois.publication.titleMicroorganisms
degois.publication.volume10
dspace.entity.typePublication
person.familyNameCalhau
person.givenNameConceição
person.identifier.ciencia-id2110-0420-1717
person.identifier.orcid0000-0001-9567-3379
person.identifier.scopus-author-id6701578877
rcaap.rightsopenAccess
relation.isAuthorOfPublication32b016c8-810a-40be-b9ee-ddfb07668a78
relation.isAuthorOfPublication.latestForDiscovery32b016c8-810a-40be-b9ee-ddfb07668a78

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