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Unveiling the biopathway for the design of novel COMT inhibitors

2022-10Recensão Acesso aberto
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dc.contributor.authorCruz-Vicente, Pedro
dc.contributor.authorGonçalves, Ana M.
dc.contributor.authorBarroca-Ferreira, Jorge
dc.contributor.authorSilvestre, Samuel M.
dc.contributor.authorRomão, Maria J.
dc.contributor.authorQueiroz, João A.
dc.contributor.authorGallardo, Eugénia
dc.contributor.authorPassarinha, Luís A.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier
dc.date.accessioned2023-10-06T22:17:57Z
dc.date.available2023-10-06T22:17:57Z
dc.date.issued2022-10
dc.descriptionFunding Information: The authors acknowledge support from FEDER funds through the POCI – COMPETE 2020 – Operational Programme Competitiveness and Internationalisation in Axis I – Strengthening Research, Technological Development and innovation (Project POCI-01-0145-FEDER-007491). Publisher Copyright: © 2022 Elsevier Ltd
dc.description.abstractCatechol-O-methyltransferase (COMT) is an enzyme responsible for the O-methylation of biologically active catechol-based molecules. It has been associated with several neurological disorders, especially Parkinson's disease (PD), because of its involvement in catecholamine metabolism, and has been considered an important therapeutic target for central nervous system disorders. In this review, we summarize the biophysical, structural, and therapeutical relevance of COMT; the medicinal chemistry behind the development of COMT inhibitors and the application of computer-aided design to support the design of novel molecules; current methodologies for the biosynthesis, isolation, and purification of COMT; and revise existing bioanalytical approaches for the assessment of enzymatic activity in several biological matrices.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent461021
dc.identifier.doi10.1016/j.drudis.2022.07.013
dc.identifier.issn1359-6446
dc.identifier.otherPURE: 55867393
dc.identifier.otherPURE UUID: d36a48d0-849d-44ee-9919-fc23f0ed7e59
dc.identifier.otherScopus: 85135397812
dc.identifier.otherPubMed: 35907613
dc.identifier.otherWOS: 000862832600021
dc.identifier.urihttp://hdl.handle.net/10362/158732
dc.identifier.urlhttps://www.scopus.com/pages/publications/85135397812
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationHealth Sciences Research Centre
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationInstitute for Health and Bioeconomy
dc.relationBiointeration studies of membrane-bound catechol-O-methyltransferase polymorphic variants with commercial Parkinson’s inhibitors
dc.relationStructural and Functional Characterization of the Cancer-associated Epithelial Antigen STEAP1
dc.relationStructural and Functional Characterization of Cancer-associated Epithelial Antigen STEAP1
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F147519%2F2019/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F130068%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBSAB%2F150376%2F2019/PT
dc.subjectBioanalytical methods
dc.subjectCatechol-O-methyltransferase
dc.subjectComputer-aided drug design
dc.subjectCOMT inhibitors
dc.subjectUp-/down-stream processing
dc.subjectPharmacology
dc.subjectDrug Discovery
dc.titleUnveiling the biopathway for the design of novel COMT inhibitorsen
dc.typereview
degois.publication.issue10
degois.publication.titleDrug Discovery Today
degois.publication.volume27
dspace.entity.typePublication
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oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleHealth Sciences Research Centre
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleInstitute for Health and Bioeconomy
oaire.awardTitleBiointeration studies of membrane-bound catechol-O-methyltransferase polymorphic variants with commercial Parkinson’s inhibitors
oaire.awardTitleStructural and Functional Characterization of the Cancer-associated Epithelial Antigen STEAP1
oaire.awardTitleStructural and Functional Characterization of Cancer-associated Epithelial Antigen STEAP1
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FMulti%2F00709%2F2013/PT
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oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F147519%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F130068%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBSAB%2F150376%2F2019/PT
oaire.fundingStream6817 - DCRRNI ID
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oaire.fundingStreamOE
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