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Measuring quality of life of patients with axial spondyloarthritis for economic evaluation

2022-02-01Artigo científico Acesso aberto
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dc.contributor.authorHernandez Alava, Monica
dc.contributor.authorWailoo, Allan
dc.contributor.authorChrysanthou, Georgios
dc.contributor.authorBarcelos, Filipe
dc.contributor.authorvan Gaalen, Floris A.
dc.contributor.authorSantos, Helena
dc.contributor.authorFagerli, Karen Minde
dc.contributor.authorGago, Laura
dc.contributor.authorMargarida Cunha, Maria
dc.contributor.authorvan de Sande, Marleen
dc.contributor.authorCouto, Maura C.
dc.contributor.authorBernardes, Miguel
dc.contributor.authorRamonda, Roberta
dc.contributor.authorRamonda, Roberta
dc.contributor.authorExarchou, Sofia
dc.contributor.authorCarvalho, Pedro D.
dc.contributor.authorvan der Heijde, Desirée
dc.contributor.authorMachado, Pedro M.
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblBMJ Publishing Group
dc.date.accessioned2022-03-08T23:23:02Z
dc.date.available2022-03-08T23:23:02Z
dc.date.issued2022-02-01
dc.descriptionPublisher Copyright: © Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
dc.description.abstractOBJECTIVES: To estimate the relationship between EQ5D (three levels, UK version) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) for use in the economic evaluation of health technologies for people with axial spondyloarthritis (axSpA). To compare against the relationship with the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI). METHODS: An electronic, prospective, Portuguese, nationwide, rheumatic disease register (Reuma.pt) provided data on 1140 patients (5483 observations) with a confirmed diagnosis of axSpA. We estimated models of EQ5D as a function of ASDAS, alone or in combination with measures of functional impairment, using bespoke mixture models which reflect the complex distributional features of EQ5D. The SPondyloArthritis Caught Early cohort provided data from 344 patients (1405 observations) in four European countries and was used for validation. A previously published model of BASDAI/Bath Ankylosing Spondylitis Functional Index (BASFI) was also used to generate predicted EQ5D scores and model performance compared. RESULTS: A non-linear relationship exists between EQ5D from ASDAS. The final model included ASDAS, ASDAS squared, age and age squared and demonstrated close fit in both datasets except where data were sparse for patients with very high levels of disease activity (ASDAS >4). This finding held in the validation dataset. Models that included BASFI improved model fit. The ASDAS based models fit the data marginally less well than models using BASDAI. CONCLUSIONS: Mapping models linking ASDAS to EQ5D allow results from clinical studies to be used in economic evaluation of health technologies with confidence. There is some loss of information compared with BASDAI but this has only a marginal impact.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent448591
dc.identifier.doi10.1136/rmdopen-2021-001955
dc.identifier.issn2044-6055
dc.identifier.otherPURE: 41998594
dc.identifier.otherPURE UUID: e72ebede-947b-4bc2-9587-2cc7ad543c53
dc.identifier.otherScopus: 85124774577
dc.identifier.otherPubMed: 35177554
dc.identifier.urihttp://hdl.handle.net/10362/134131
dc.identifier.urlhttps://www.scopus.com/pages/publications/85124774577
dc.language.isoeng
dc.peerreviewedyes
dc.subjectankylosing
dc.subjecteconomics
dc.subjectpatient reported outcome measures
dc.subjectspondylitis
dc.subjectImmunology and Allergy
dc.subjectRheumatology
dc.subjectImmunology
dc.titleMeasuring quality of life of patients with axial spondyloarthritis for economic evaluationen
dc.typejournal article
degois.publication.issue1
degois.publication.titleRMD Open
degois.publication.volume8
dspace.entity.typePublication
person.familyNameRamonda
person.givenNameRoberta
person.identifier958230
person.identifier.orcid0000-0002-9683-8873
person.identifier.scopus-author-id6701382110
rcaap.rightsopenAccess
relation.isAuthorOfPublication56bf5324-4068-41cd-aab6-b397301cc9db
relation.isAuthorOfPublication.latestForDiscovery56bf5324-4068-41cd-aab6-b397301cc9db

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