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Di iron Proteins with Cell Repair Functions in Pathogens
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"Repair of Iron Centres (RIC) proteins are a family of di-iron hemerythrin-like proteins widely spread among pathogens, such as Escherichia coli and Staphylococcus aureus. RICs restore the activity of stress damaged iron-sulfur (Fe-S) containing proteins, such as those acting in the tricarboxylic acid cycle, namely aconitase and fumarase. Moreover, E. coli RIC (herein designed as YtfE) is able to provide iron for the assembly of Fe-S clusters in apo- and scaffold proteins.(...)"
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E. coli YtfE bacterial RIC proteins