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Portuguese guidelines for the use of biological agents in rheumatoid arthritis - March 2010 update.

2010-01Artigo científico Acesso aberto
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dc.contributor.authorFonseca, João Eurico
dc.contributor.authorCanhão, Helena
dc.contributor.authorCanhão, Helena
dc.contributor.authorReis, Paulo
dc.contributor.authorSantos, Maria José
dc.contributor.authorBranco, Jaime
dc.contributor.authorBranco, Jaime
dc.contributor.authorQuintal, Alberto
dc.contributor.authorMalcata, Armando
dc.contributor.authorAraújo, Domingos
dc.contributor.authorVentura, Francisco
dc.contributor.authorFigueiredo, Guilherme
dc.contributor.authorda Silva, José Canas
dc.contributor.authorPatto, José Vaz
dc.contributor.authorQueiroz, Mário Viana
dc.contributor.authorSantos, Rui André
dc.contributor.authorNeto, Adriano José
dc.contributor.authorde Matos, J. Alves
dc.contributor.authorRodrigues, Ana
dc.contributor.authorMaria Rodrigues, Ana
dc.contributor.authorMourão, Ana Filipa
dc.contributor.authorRibeiro, Ana Sofia
dc.contributor.authorCravo, Ana Rita
dc.contributor.authorBarcelos, Anabela
dc.contributor.authorCardoso, Anabela
dc.contributor.authorVilar, António
dc.contributor.authorBraña, Arecili
dc.contributor.authorFaustino, Augusto
dc.contributor.authorSilva, Candida
dc.contributor.authorGodinho, Fátima
dc.contributor.authorCunha, Inês
dc.contributor.authorCosta, José António
dc.contributor.authorGomes, José António Melo
dc.contributor.authorPinto, José António Araújo
dc.contributor.authorda Silva, José António Pereira
dc.contributor.authorMiranda, Luís Cunha
dc.contributor.authorInês, Luís Sousa
dc.contributor.authorSantos, Luís Maurício
dc.contributor.authorCruz, Margarida
dc.contributor.authorSalvador, Maria João
dc.contributor.authorFerreira, Maria Júlia
dc.contributor.authorRial, Maria
dc.contributor.authorBernardes, Miguel
dc.contributor.authorBogas, Mónica
dc.contributor.authorAraújo, Paula
dc.contributor.authorMachado, Pedro
dc.contributor.authorPinto, Patrícia
dc.contributor.authorde Melo, Rui Gomes
dc.contributor.authorCortes, Sara
dc.contributor.authorAlcino, Sérgio
dc.contributor.authorCapela, Susana
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblSociedade Portuguesa de Reumatologia
dc.date.accessioned2017-07-17T22:01:37Z
dc.date.available2017-07-17T22:01:37Z
dc.date.issued2010-01
dc.description.abstractThe authors present the revised version of the Portuguese Society of Rheumatology (SPR) guidelines for the treatment of rheumatoid arthritis (RA) with biological therapies. In these guidelines the criteria for introduction and maintenance of biological agents are discussed as well as the contraindications and procedures in the case of non-responders. Biological treatment should be considered in RA patients with a disease activity score 28 (DAS 28) superior to 3.2 despite treatment with 20mg/week of methotrexate (MTX) for at least 3 months or, if such treatment is not possible, after 6 months of other conventional disease modifying drug or combination therapy. A DAS 28 score between 2.6 and 3.2 with a significant functional or radiological deterioration under treatment with conventional regimens could also constitute an indication for biological treatment. The treatment goal should be remission or, if that is not achievable, at least a low disease activity, characterized by a DAS28 lower than 3.2, without significative functional or radiological worsening. The response criteria, at the end of the first 3 months of treatment, are a decrease of 0.6 in the DAS28 score. After 6 months of treatment response criteria is defined as a decrease of more than 1.2 in the DAS28 score. Non-responders, in accordance to the Rheumatologist's clinical opinion, should try a switch to another biological agent (tumour necrosis factor antagonist, abatacept, rituximab or tocilizumab).en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent4
dc.format.extent53064
dc.identifier.issn0303-464X
dc.identifier.otherPURE: 2304087
dc.identifier.otherPURE UUID: 66c3644d-59f5-438d-8b33-4df39a93f0a2
dc.identifier.otherScopus: 77957598053
dc.identifier.otherPubMed: 20505635
dc.identifier.otherWOS: 000277583100016
dc.identifier.otherORCID: /0000-0003-1894-4870/work/67178119
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=77957598053&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/77957598053
dc.language.isoeng
dc.peerreviewedyes
dc.subjectArtrite Reumatóide
dc.subjectTerapêutica Biológica
dc.subjectAnti-TNF
dc.subjectRituximab
dc.subjectAbatacept
dc.subjectTocilizumab
dc.subjectRheumatology
dc.titlePortuguese guidelines for the use of biological agents in rheumatoid arthritis - March 2010 update.en
dc.typejournal article
degois.publication.firstPage95
degois.publication.issue1
degois.publication.lastPage98
degois.publication.titleActa Reumatológica Portuguesa
degois.publication.volume35
dspace.entity.typePublication
person.familyNameCanhão
person.familyNameBranco
person.familyNameRodrigues
person.givenNameHelena
person.givenNameJaime
person.givenNameAna Maria
person.identifier379800
person.identifier405554
person.identifier.ciencia-id5A17-C6D9-DBC8
person.identifier.ciencia-idB612-E5C3-60DC
person.identifier.ciencia-idAE18-DA10-460C
person.identifier.orcid0000-0003-1894-4870
person.identifier.orcid0000-0001-7024-4375
person.identifier.orcid0000-0003-2046-8017
person.identifier.ridC-9611-2018
person.identifier.scopus-author-id6602393492
person.identifier.scopus-author-id8417815400
person.identifier.scopus-author-id57189499663
rcaap.rightsopenAccess
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relation.isAuthorOfPublication4caea9f3-40dd-4c95-98ec-0120509287c0
relation.isAuthorOfPublicatione2b860b7-6a22-4bc8-a7ff-676ca22da61c
relation.isAuthorOfPublication.latestForDiscoverye2b860b7-6a22-4bc8-a7ff-676ca22da61c

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