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Silica-based optical chemosensors for rapid and reliable on-site detection of gamma-hydroxybutyrate in beverages and oral fluids

2025-05Artigo científico Acesso aberto
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dc.contributor.authorHernández-Contreras, Jordi
dc.contributor.authorRoig-Rubio, Jordi
dc.contributor.authorParra, Margarita
dc.contributor.authorGil, Salvador
dc.contributor.authorArroyo, Pau
dc.contributor.authorSáez, José A.
dc.contributor.authorLodeiro, Carlos
dc.contributor.authorGaviña, Pablo
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.pblSpringer Science Business Media
dc.date.accessioned2025-06-20T21:14:32Z
dc.date.available2025-06-20T21:14:32Z
dc.date.issued2025-05
dc.descriptionFunding Information: The authors gratefully acknowledge grant PID2021-126304OB-C42 funded by the Spanish MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe, EU”, and grant PDC2022-133576-C22 funded by the Spanish MCIN/AEI/10.13039/501100011033 and by the European Union “NextGenerationEU/PRTR”. This work also received partial support and help from Associate Laboratory for Green Chemistry—LAQV which is financed by national funds from FCT/MCTES (UIDB/50006/2020 and UIDP/50006/2020) through national funds. The PROTEOMASS Scientific Society (Portugal) is also acknowledged by the funding provided through the General Funding Grant 2023. SCSIE (Universidad de Valencia) is gratefully acknowledged for all the equipment employed. NMR was registered at the U26 facility of ICTS “NAMBIOSIS” at the Universitat of València. Publisher Copyright: © The Author(s) 2025.
dc.description.abstractThe illicit use of gamma-hydroxybutyrate (GHB) in drug-facilitated crimes underscores the urgent need for rapid and reliable detection technologies. This study introduces two innovative silica-based nanosensors that offer real-time, on-site detection of GHB in spiked beverages at concentrations typical of chemical submission cases. Both chemosensors are based on silica nanoparticles functionalized with 2-aminonaphtoxazole derivatives. The first nanosensor, modified with a p-nitroaniline chromogenic unit, enables a visible color change for immediate visual identification, while the second incorporates a fluorescein derivative for high-sensitivity detection via fluorescence. Both nanosystems demonstrate exceptional specificity to GHB, with minimal interference from other substances. Moreover, the solid-phase integration of these nanosensors onto hydrophobic cellulose-based substrates enhances their portability and user-friendliness, making them suitable for nightlife venues and forensic applications. Finally, chromogenic precursor 1 has proven to be an excellent chemosensor for the visual detection of GHB in oral fluid, with a calculated LOD of 19.2 μM, and a linear response in the 32–132 μM range.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent14
dc.format.extent3275482
dc.identifier.doi10.1007/s00604-025-07134-9
dc.identifier.issn0026-3672
dc.identifier.otherPURE: 118930729
dc.identifier.otherPURE UUID: cce14b09-659a-4175-9301-5ce35964ad9b
dc.identifier.otherScopus: 105001736412
dc.identifier.otherPubMed: 40175785
dc.identifier.otherWOS: 001458232500001
dc.identifier.otherPubMed: 40175785
dc.identifier.otherPubMedCentral: PMC11965150
dc.identifier.otherORCID: /0000-0001-5582-5446/work/201987788
dc.identifier.urihttp://hdl.handle.net/10362/184286
dc.identifier.urlhttps://www.scopus.com/pages/publications/105001736412
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001458232500001
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT
dc.subjectChemical submission
dc.subjectChromo-fluorogenic chemosensors
dc.subjectGamma-hydroxybutyrate (GHB)
dc.subjectOral fluids
dc.subjectSilica nanoparticles
dc.subjectSpiked drinks
dc.subjectAnalytical Chemistry
dc.subjectSDG 16 - Peace, Justice and Strong Institutions
dc.titleSilica-based optical chemosensors for rapid and reliable on-site detection of gamma-hydroxybutyrate in beverages and oral fluidsen
dc.typejournal article
degois.publication.firstPage1
degois.publication.lastPage14
degois.publication.titleMicrochimica Acta
degois.publication.volume192
dspace.entity.typePublication
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50006%2F2020/PT
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication186df1fb-72e1-4b5e-bb56-1760cf233cbe
relation.isProjectOfPublicationae403dd6-3940-45dd-a7c4-04c6bec15552
relation.isProjectOfPublication.latestForDiscovery186df1fb-72e1-4b5e-bb56-1760cf233cbe

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