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AFTER-CA

2024-10Artigo científico Acesso aberto
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dc.contributor.authorFerreira, Monica
dc.contributor.authorFerreira, Mónica
dc.contributor.authorCunha, Pedro Silva
dc.contributor.authorSilva Cunha, Pedro
dc.contributor.authorFelix, Ana Clara
dc.contributor.authorFonseca, Helena
dc.contributor.authorOliveira, Mario
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorLaranjo, Sergio
dc.contributor.authorRocha, Isabel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-10-22T23:36:52Z
dc.date.available2024-10-22T23:36:52Z
dc.date.issued2024-10
dc.descriptionPublisher Copyright: © 2024 by the authors.
dc.description.abstractBackground: Catheter ablation (CA) is a well-established treatment for atrial fibrillation (AF). However, its effects on autonomic function and underlying mechanisms remain poorly understood. This study investigated autonomic and haemodynamic changes following CA and explored their potential implications for patient outcomes. Methods: Seventy-eight patients with AF underwent CA and were followed up at one, three, and six months. Autonomic function was assessed using a combination of head-up tilt (HUT), handgrip (HG), and deep breathing (DB) manoeuvres along with baroreflex sensitivity (BRS) and baroreflex effectiveness index (BEI) evaluation. Heart rate (HR), blood pressure (BP), and their variability were measured at each time point. Results: Significant autonomic alterations were observed after ablation, particularly at one month, with reductions in parasympathetic tone and baroreflex function. These changes gradually normalised by six months. Both pulmonary vein isolation (PVI) and cryoablation (CryO) had similar effects on autonomic regulation. Improvements in quality of life, measured by the AFEQT scores, were consistent with these physiological changes. Conclusions: CA for AF induces significant time-dependent autonomic and haemodynamic changes with recovery over six months. These findings underscore the need for ongoing monitoring and personalised post-ablation management. Further research is required to explore the mechanisms driving these alterations and their long-term impacts on patient outcomes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3968328
dc.identifier.doi10.3390/jcm13195796
dc.identifier.issn2077-0383
dc.identifier.otherPURE: 101765352
dc.identifier.otherPURE UUID: 5c7c4207-59f3-414a-8748-7c9eeebb8650
dc.identifier.otherScopus: 85206444494
dc.identifier.urihttp://hdl.handle.net/10362/173919
dc.identifier.urlhttps://www.scopus.com/pages/publications/85206444494
dc.language.isoeng
dc.peerreviewedyes
dc.subjectatrial fibrillation
dc.subjectautonomic function
dc.subjectbaroreflex sensitivity
dc.subjectcatheter ablation
dc.subjectcryoablation
dc.subjectheart rate variability
dc.subjectpulmonary vein isolation
dc.subjectquality of life
dc.subjectGeneral Medicine
dc.titleAFTER-CAen
dc.title.subtitleAutonomic Function Transformation and Evaluation Following Catheter Ablation in Atrial Fibrillationen
dc.typejournal article
degois.publication.issue19
degois.publication.titleJournal of Clinical Medicine
degois.publication.volume13
dspace.entity.typePublication
person.familyNameFerreira
person.familyNameSilva Cunha
person.familyNameLaranjo
person.givenNameMónica
person.givenNamePedro
person.givenNameSergio
person.identifier1235667
person.identifier36332
person.identifier.ciencia-id6C1E-26F2-E6A4
person.identifier.ciencia-id4716-747F-D64E
person.identifier.ciencia-id351B-92E1-0C50
person.identifier.orcid0000-0002-7066-7770
person.identifier.orcid0000-0001-9465-634X
person.identifier.orcid0000-0003-2169-4024
person.identifier.ridG-2909-2011
person.identifier.scopus-author-id6504508117
person.identifier.scopus-author-id24391148400
rcaap.rightsopenAccess
relation.isAuthorOfPublicationabaf2902-b61d-42a1-930e-c52ed15b7fa9
relation.isAuthorOfPublicationdf90a32b-106b-4f14-bcab-6b473ef59d68
relation.isAuthorOfPublication57b8fd07-1401-449a-8678-0d4c9eaca5db
relation.isAuthorOfPublication.latestForDiscovery57b8fd07-1401-449a-8678-0d4c9eaca5db

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