Logo do repositório
 
Publicação

Adaptive potential of hybridization among malaria vectors

2015-06-05Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMancini, Emiliano
dc.contributor.authorSpinaci, Maria Ida
dc.contributor.authorGordicho, Vasco
dc.contributor.authorCaputo, Beniamino
dc.contributor.authorPombi, Marco
dc.contributor.authorVicente, José Luis
dc.contributor.authorDinis, João
dc.contributor.authorRodrigues, Amabélia
dc.contributor.authorPetrarca, Vincenzo
dc.contributor.authorWeetman, David
dc.contributor.authorPinto, João
dc.contributor.authorTorre, Alessandra Della
dc.contributor.institutionInstituto de Higiene e Medicina Tropical (IHMT)
dc.contributor.institutionCentro de Malária e outras Doenças Tropicais (CMDT)
dc.contributor.pblPLOS - Public Library of Science
dc.date.accessioned2018-05-14T22:02:06Z
dc.date.available2018-05-14T22:02:06Z
dc.date.issued2015-06-05
dc.descriptionPMID: 26047479 WOS:000355652200031
dc.description.abstract"Far-West" Africa is known to be a secondary contact zone between the two major malaria vectors Anopheles coluzzii and A. gambiae. We investigated gene-flow and potentially adaptive introgression between these species along a west-to-east transect in Guinea Bissau, the putative core of this hybrid zone. To evaluate the extent and direction of gene flow, we genotyped site 702 in Intron-1 of the para Voltage-Gated Sodium Channel gene, a species-diagnostic nucleotide position throughout most of A. coluzzii and A. gambiae sympatric range. We also analyzed polymorphism in the thioester-binding domain (TED) of the innate immunity-linked thioester-containing protein 1 (TEP1) to investigate whether elevated hybridization might facilitate the exchange of variants linked to adaptive immunity and Plasmodium refractoriness. Our results confirm asymmetric introgression of genetic material from A. coluzzii to A. gambiae and disruption of linkage between the centromeric "genomic islands" of inter-specific divergence. We report that A. gambiae from the Guinean hybrid zone possesses an introgressed TEP1 resistant allelic class, found exclusively in A. coluzzii elsewhere and apparently swept to fixation in West Africa (i.e. Mali and Burkina Faso). However, no detectable fixation of this allele was found in Guinea Bissau, which may suggest that ecological pressures driving segregation between the two species in larval habitats in this region may be different from those experienced in northern and more arid parts of the species' range. Finally, our results also suggest a genetic subdivision between coastal and inland A. gambiae Guinean populations and provide clues on the importance of ecological factors in intra-specific differentiation processes.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1383379
dc.identifier.doi10.1371/journal.pone.0127804
dc.identifier.issn1932-6203
dc.identifier.otherPURE: 1728870
dc.identifier.otherPURE UUID: bf07dd9f-c718-467c-b108-d03f78e1514e
dc.identifier.otherScopus: 84934942312
dc.identifier.otherWOS: 000355652200031
dc.identifier.otherPubMed: 26047479
dc.identifier.otherORCID: /0000-0001-8572-7708/work/81722265
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=84934942312&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/84934942312
dc.language.isoeng
dc.peerreviewedyes
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectGenetics
dc.subjectInsect Science
dc.subjectInfectious Diseases
dc.subjectImmunology
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAdaptive potential of hybridization among malaria vectorsen
dc.title.subtitleIntrogression at the immune locus TEP1 between Anopheles coluzzii and A. gambiae in 'Far-West' Africaen
dc.typejournal article
degois.publication.issue6
degois.publication.titlePLoS ONE
degois.publication.volume10
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Adaptive_potential_of_hybridization_among_malaria_vectors.pdf
Tamanho:
1.32 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

IHMT: PM - Artigos em revista internacional com arbitragem científica