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Paraoxonase-1 as a Regulator of Glucose and Lipid Homeostasis

2019-08-19Recensão Acesso aberto
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dc.contributor.authorMeneses, Maria João
dc.contributor.authorSilvestre, Regina
dc.contributor.authorSousa-Lima, Inês
dc.contributor.authorMacedo, Maria Paula
dc.contributor.institutionCentro de Estudos de Doenças Crónicas (CEDOC)
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionFaculdade de Ciências e Tecnologia (FCT)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2019-09-26T22:47:03Z
dc.date.available2019-09-26T22:47:03Z
dc.date.issued2019-08-19
dc.descriptionThis work was funded by the "Fundacao para a Ciencia e a Tecnologia"-FCT to Maria J. Meneses (PD/BD/114256/2016); M. Paula Macedo (PTDC/DTP-EPI/0207/2012, PTDC/BIM-MET/2115/2014 and PTDC/BIM-MET/4265/2014); and iNOVA4Health (UID/Multi/04462/2013); by the European Commission Marie Sklodowska-Curie Actions H2020 (grant agreements no. 722619 and no. 734719), and by the Sociedade Portuguesa de Diabetologia GIFT 2018.
dc.description.abstractMetabolic disorders are characterized by an overall state of inflammation and oxidative stress, which highlight the importance of a functional antioxidant system and normal activity of some endogenous enzymes, namely paraoxonase-1 (PON1). PON1 is an antioxidant and anti-inflammatory glycoprotein from the paraoxonases family. It is mainly expressed in the liver and secreted to the bloodstream, where it binds to HDL. Although it was first discovered due to its ability to hydrolyze paraoxon, it is now known to have an antiatherogenic role. Recent studies have shown that PON1 plays a protective role in other diseases that are associated with inflammation and oxidative stress, such as Type 1 and Type 2 Diabetes Mellitus and Non-Alcoholic Fatty Liver Disease. The aim of this review is to elucidate the physiological role of PON1, as well as the impact of altered PON1 levels in metabolic disorders.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1090797
dc.identifier.doi10.3390/ijms20164049
dc.identifier.issn1422-0067
dc.identifier.otherPURE: 14699127
dc.identifier.otherPURE UUID: 3c807e25-9118-4b18-a694-641830856ea5
dc.identifier.otherScopus: 85071756236
dc.identifier.otherPubMed: 31430977
dc.identifier.otherWOS: 000484411100206
dc.identifier.urihttp://www.scopus.com/inward/record.url?scp=85071756236&partnerID=8YFLogxK
dc.identifier.urlhttps://www.scopus.com/pages/publications/85071756236
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/124357/PT
dc.relationInsulin Clearance (Dys)Regulation: clarifying the mist.
dc.relationBioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
dc.relationmitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease
dc.subjectdiabetes mellitus
dc.subjectglucose
dc.subjectinsulin resistance
dc.subjectNAFLD
dc.subjectobesity
dc.subjectPON1
dc.subjectCatalysis
dc.subjectMolecular Biology
dc.subjectSpectroscopy
dc.subjectComputer Science Applications
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectInorganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.titleParaoxonase-1 as a Regulator of Glucose and Lipid Homeostasisen
dc.title.subtitleImpact on the Onset and Progression of Metabolic Disordersen
dc.typereview
degois.publication.issue16
degois.publication.titleInternational Journal of Molecular Sciences
degois.publication.volume20
dspace.entity.typePublication
oaire.awardNumberPTDC/DTP-EPI/0207/2012
oaire.awardNumberUID/Multi/04462/2013
oaire.awardNumber722619
oaire.awardNumber734719
oaire.awardTitleInsulin Clearance (Dys)Regulation: clarifying the mist.
oaire.awardTitleBioenergetic Remodeling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease
oaire.awardTitlemitoFOIE GRAS: Non-invasive Profiling of Mitochondrial Function in Non-Alcoholic Fatty Liver Disease
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FDTP-EPI%2F0207%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FMulti%2F04462%2F2013/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/722619/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/734719/EU
oaire.fundingStream3599-PPCDT
oaire.fundingStream5876
oaire.fundingStreamH2020
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccess
relation.isProjectOfPublication01a3aa4e-73db-4c99-897a-cab758f8ac74
relation.isProjectOfPublication828e3044-8984-4282-bc90-98654cc2323e
relation.isProjectOfPublicationa7de4770-2e1e-4c7f-a169-db20b3b43776
relation.isProjectOfPublication6491df4a-19c5-4784-ac08-1f716106a6cd
relation.isProjectOfPublication.latestForDiscovery6491df4a-19c5-4784-ac08-1f716106a6cd

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