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Methicillin-Resistant Staphylococcus aureus

2025-01Artigo científico Acesso aberto
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dc.contributor.authorBoucherabine, Syrine
dc.contributor.authorNassar, Rania
dc.contributor.authorMohamed, Lobna
dc.contributor.authorHabous, Maya
dc.contributor.authorNabi, Anju
dc.contributor.authorHusain, Riyaz Amirali
dc.contributor.authorAlfaresi, Mubarak
dc.contributor.authorOommen, Seema
dc.contributor.authorOommen, Seema
dc.contributor.authorKhansaheb, Hamda Hassan
dc.contributor.authorAl Sharhan, Mouza
dc.contributor.authorCeliloglu, Handan
dc.contributor.authorRaja, Mubarak Hussain
dc.contributor.authorAbdelkarim, Eman
dc.contributor.authorEl-Sayed, Eman
dc.contributor.authorAli, Nishi
dc.contributor.authorTausif, Salman
dc.contributor.authorOlowoyeye, Victory
dc.contributor.authorSoares, Nelson Cruz
dc.contributor.authorSoares, Nelson C
dc.contributor.authorHachim, Mahmood
dc.contributor.authorMoradigaravand, Danesh
dc.contributor.authorMoradigaravand, Danesh
dc.contributor.authorEverett, Dean
dc.contributor.authorEverett, Dean
dc.contributor.authorMueller, Elke
dc.contributor.authorMonecke, Stefan
dc.contributor.authorMonecke, Stefan
dc.contributor.authorEhricht, Ralf
dc.contributor.authorEhricht, Ralf
dc.contributor.authorSenok, Abiola
dc.contributor.authorSenok, Abiola
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionCentre for Toxicogenomics and Human Health (ToxOmics)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-02-10T21:19:55Z
dc.date.available2025-02-10T21:19:55Z
dc.date.issued2025-01
dc.descriptionPublisher Copyright: © 2025 by the authors.
dc.description.abstractBackground: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant burden globally, particularly in the Arabian Gulf region. The United Arab Emirates (UAE) has experienced rising MRSA prevalence, with increasing diversity in the clonal complexes (CCs) identified. The COVID-19 pandemic, with its increased hospitalization rates and antibiotic use, may have further influenced MRSA’s genetic evolution and epidemiology in the country. Methods: To investigate this influence, genomic profiling of 310 MRSA clinical isolates collected between February and November 2022 was performed using a DNA microarray-based assay. Results: Isolates were assigned to 22 clonal complexes and 72 distinct strain assignments. The predominant clonal complexes were CC5, CC6, CC361, CC22, CC1, and CC8. Community-acquired MRSA lineages were dominant, with only one healthcare-associated MRSA lineage isolate identified. Upward trends of CC1153 were observed along with rare CCs, such as CC121-MRSA and CC7-MRSA, with the latter being reported for the first time in the Arabian Gulf region. The presence of pandemic strains USA300 CC8-MRSA-[IVa + ACME1] and CC8-MRSA-IV strains were also observed, including variants lacking Panton–Valentine leukocidin (pvl) genes and missing tst1 or enterotoxin genes. The PVL-negative CC772-MRSA-V/VT was identified, representing its first report in the UAE. A novel variant, CC361-MRSA-IV (tst1+/PVL+), was identified. Pvl genes were observed in 36% of the isolates, primarily from skin and soft tissue infections, while fusC (SCC-borne fusidic acid resistance) was identified in 13% of the isolates. Conclusions: The findings highlight the ongoing evolution of MRSA in the UAE, with the persistence and emergence of diverse and rare clonal complexes, driving the need for continuous genomic surveillance.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent516991
dc.identifier.doi10.3390/antibiotics14010024
dc.identifier.issn2079-6382
dc.identifier.otherPURE: 109216665
dc.identifier.otherPURE UUID: 717553fb-6aca-4998-b78b-b5e1ac7eb832
dc.identifier.otherScopus: 85215669295
dc.identifier.urihttp://hdl.handle.net/10362/178780
dc.identifier.urlhttps://www.scopus.com/pages/publications/85215669295
dc.language.isoeng
dc.peerreviewedyes
dc.subjectantimicrobial resistance
dc.subjectgenotyping
dc.subjectmicroarray
dc.subjectMRSA
dc.subjectStaphylococcus aureus
dc.subjectMicrobiology
dc.subjectBiochemistry
dc.subjectPharmacology, Toxicology and Pharmaceutics(all)
dc.subjectMicrobiology (medical)
dc.subjectInfectious Diseases
dc.subjectPharmacology (medical)
dc.subjectSDG 3 - Good Health and Well-being
dc.titleMethicillin-Resistant Staphylococcus aureusen
dc.title.subtitleThe Shifting Landscape in the United Arab Emiratesen
dc.typejournal article
degois.publication.issue1
degois.publication.titleAntibiotics
degois.publication.volume14
dspace.entity.typePublication
person.familyNameoommen
person.familyNameEl-Sayed
person.familyNameda Cruz Soares
person.familyNameMoradigaravand
person.familyNameEverett
person.familyNamemonecke
person.familyNameEhricht
person.familyNameSenok
person.givenNameseema
person.givenNameEman
person.givenNameNelson
person.givenNameDanesh
person.givenNameDean
person.givenNamestefan
person.givenNameRalf
person.givenNameAbiola
person.identifier166299
person.identifier353090
person.identifier.ciencia-id7D1B-7846-AB69
person.identifier.orcid0000-0002-0728-7783
person.identifier.orcid0009-0009-6054-4978
person.identifier.orcid0000-0003-2331-8532
person.identifier.orcid0000-0001-6652-5617
person.identifier.orcid0000-0002-8458-6779
person.identifier.orcid0000-0003-4368-8709
person.identifier.orcid0000-0002-6612-0043
person.identifier.orcid0000-0001-6382-198X
person.identifier.scopus-author-id6603685292
person.identifier.scopus-author-id55441387400
person.identifier.scopus-author-id19933714900
person.identifier.scopus-author-id6507331569
rcaap.rightsopenAccess
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