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The study of galactomannans with different molecular weights and their ability to form microparticles suitable for pulmonary delivery

2024-09-01Artigo científico Acesso aberto
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dc.contributor.authorGalrinho, Miguel F.
dc.contributor.authorSilva, Lisete M.
dc.contributor.authorLopes, Guido R.
dc.contributor.authorFerreira, Bernardo A.C.
dc.contributor.authorValente, Sara A.
dc.contributor.authorFerreira, Isabel
dc.contributor.authorPinheiro, Benedita A.
dc.contributor.authorPalma, Angelina S.
dc.contributor.authorEvtuguin, Dmitry V.
dc.contributor.authorLopes da Silva, José A.
dc.contributor.authorAlmeida, Margarida
dc.contributor.authorFerreira, Paula
dc.contributor.authorCruz, Maria T.
dc.contributor.authorCoimbra, Manuel A.
dc.contributor.authorPassos, Cláudia P.
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier
dc.date.accessioned2025-03-06T21:55:16Z
dc.date.available2025-03-06T21:55:16Z
dc.date.issued2024-09-01
dc.descriptionSara Valente and Cláudia Passos thank FCT for the individual grant (DFA/BD/5430/2020). © 2024 The Authors. Published by Elsevier Ltd.
dc.description.abstractThe influence of locust bean gum (LBG) galactomannans (GMs) molecular weight (Mw) to assemble microparticulate systems was evaluated, and carriers for deep lung delivery were developed. A commercial batch of LBG with a mannose/galactose (M/G) ratio of 2.4 (batch 1) was used to study the influence of different microwave partial acid hydrolysis conditions on carbohydrate composition, glycosidic linkages, and aqueous solutions viscosity. The microwave treatment did not affect the composition, presenting 4-Man (36–42 %), 4,6-Man (27–35 %), and T-Gal (24–25 %) as the main glycosidic linkages. Depolymerization led to a viscosity reduction (≤0.005 Pa·s) with no major impact on polysaccharide debranching. The structural composition of the LBG galactomannans were further elucidated with sequence-specific proteins using carbohydrate microarray technologies. A second batch of LBG (M/G 3.3) was used to study the impact of GMs with different Mw on microparticle assembling, characteristics, and insulin release kinetics. The low-Mw GMs microparticles led to a faster release (20 min) than the higher-Mw (40 min) ones, impacting the release kinetics. All microparticles exhibited a safety profile to cells of the respiratory tract. However, only the higher-Mw GMs allowed the assembly of microparticles with sizes suitable for this type of administration.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent3423413
dc.identifier.doi10.1016/j.carbpol.2024.122268
dc.identifier.issn0144-8617
dc.identifier.otherPURE: 106547568
dc.identifier.otherPURE UUID: a3eee163-6a59-4423-b736-8f343d681ad6
dc.identifier.otherScopus: 85193524571
dc.identifier.otherPubMed: 38823931
dc.identifier.otherWOS: 001246278700001
dc.identifier.otherORCID: /0000-0001-5797-6555/work/179548244
dc.identifier.urihttp://hdl.handle.net/10362/180206
dc.identifier.urlhttps://www.scopus.com/pages/publications/85193524571
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50006%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50011%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50011%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0006%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00239%2F2020/PT
dc.relationForest Research Centre
dc.relationNot Available
dc.subjectCarbohydrate microarrays
dc.subjectCarob
dc.subjectInsulin
dc.subjectMicroparticles
dc.subjectMicrowave-assisted treatment
dc.subjectStructural analysis
dc.subjectOrganic Chemistry
dc.subjectPolymers and Plastics
dc.subjectMaterials Chemistry
dc.titleThe study of galactomannans with different molecular weights and their ability to form microparticles suitable for pulmonary deliveryen
dc.typejournal article
degois.publication.titleCarbohydrate Polymers
degois.publication.volume339
dspace.entity.typePublication
oaire.awardNumberUIDB/50011/2020
oaire.awardNumberUIDP/50011/2020
oaire.awardNumberLA/P/0006/2020
oaire.awardNumberUIDB/00239/2020
oaire.awardNumberCEECIND/00813/2017/CP1459/CT0053
oaire.awardTitleForest Research Centre
oaire.awardTitleNot Available
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Base/UIDB%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017%2F2018) - Financiamento Programático/UIDP%2F50011%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)/LA%2FP%2F0006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00239%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/CEEC IND 2017/CEECIND%2F00813%2F2017%2FCP1459%2FCT0053/PT
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Base
oaire.fundingStreamConcurso de avaliação no âmbito do Programa Plurianual de Financiamento de Unidades de I&D (2017/2018) - Financiamento Programático
oaire.fundingStreamConcurso para Atribuição do Estatuto e Financiamento de Laboratórios Associados (LA)
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamCEEC IND 2017
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rcaap.rightsopenAccess
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