Logo do repositório
 
Publicação

Sustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activities

2024-03-10Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorMondal, S.
dc.contributor.authorSyed, U. T.
dc.contributor.authorPinto, E.
dc.contributor.authorLeonardo, I. C.
dc.contributor.authorRomero, P.
dc.contributor.authorGaspar, F. B.
dc.contributor.authorCrespo, M. T. Barreto
dc.contributor.authorSebastian, V.
dc.contributor.authorCrespo, J. G.
dc.contributor.authorBrazinha, C.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionInstituto de Tecnologia Química e Biológica António Xavier (ITQB)
dc.contributor.pblElsevier
dc.date.accessioned2024-03-06T00:23:29Z
dc.date.available2024-03-06T00:23:29Z
dc.date.issued2024-03-10
dc.descriptionFunding Information: IL, FG, TC acknowledge funding from INTERFACE Programme, through the Innovation, Technology and Circular Economy Fund (FITEC). PR acknowledges financial support Grant PID2021-126132NB-I00 by MCIN/ AEI / 10.13039/501100011033 and the NMR Service of CEQMA (CSIC-UZ). VS acknowledges financial support Grant PID2021-127847OB-I00 and PDC2022-133866-I00 by MCIN/AEI , as well the ELECMI (LMA node) and NANBIOSIS ICTSs. Publisher Copyright: © 2024 The Authors
dc.description.abstractHydrophobic deep eutectic solvents (DESs), a recent class of green solvents, offer 100% atom economy, low cost, potential biodegradability, negligible toxicity and promising bioactivities. In this work, novel aroma-based therapeutic hydrophobic DESs were prepared and dispersed in aqueous media as nanoemulsions to potentiate biomedical applications, where polar media is encountered. A reusable microengineered stainless-steel isoporous membrane was fabricated by laser drilling technique. Three hydrophobic DESs, namely DES A (menthol and vanillin), DES B (menthol and raspberry ketone), and DES C (thymol and raspberry ketone) were prepared and emulsified in aqueous media by sustainable membrane emulsification technique. The optimised nanoemulsion (DES C-in-water) exhibited a monomodal size distribution with Zavg (size average) of 147 nm and polydispersity index of 0.22. From the application perspective, the formulated DES-in-water nanoemulsions and their constituents were evaluated for their antibacterial properties against Escherichia coli and Staphylococcus aureus. Additionally, antifungal properties of the DES-based emulsions were reported for the first time by testing them against four fungal strains, Aspergillus fumigatus, Candida albicans, Candida krusei, and Trichophyton mentagrophytes. The nanoemulsions were found to be exhibit antimicrobial effect and lesser quantities of individual compounds were needed in nanoemulsified state to show similar effects. Different 1D and 2D NMR techniques were successfully used to investigate the structural orientation and the inter and intramolecular interactions in the DES and emulsion systems, which revealed a probable cause for higher antimicrobial activity of DES C-based emulsions compared to its peers. Lastly, a synergistic effect of the components in nanoemulsions led to enhanced antimicrobial activities.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent13
dc.format.extent5600961
dc.identifier.doi10.1016/j.jclepro.2024.141167
dc.identifier.issn0959-6526
dc.identifier.otherPURE: 84620847
dc.identifier.otherPURE UUID: 49206f91-280a-4719-83d1-da2a17034c68
dc.identifier.otherScopus: 85185715254
dc.identifier.otherWOS: 001200363000001
dc.identifier.otherORCID: /0000-0001-8714-3781/work/154751513
dc.identifier.otherORCID: /0000-0002-7784-0265/work/154751647
dc.identifier.urihttp://hdl.handle.net/10362/164516
dc.identifier.urlhttps://www.scopus.com/pages/publications/85185715254
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04423%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
dc.relationInterdisciplinary Centre of Marine and Environmental Research
dc.relationiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
dc.relationiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
dc.relationLife Sciences for a Healthy and Sustainable Future
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0087%2F2020/PT
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
dc.subjectAntimicrobial properties
dc.subjectDelivery systems
dc.subjectHydrophobic deep eutectic solvent
dc.subjectNanoemulsions
dc.subjectNatural compounds
dc.subjectNMR analysis
dc.subjectRenewable Energy, Sustainability and the Environment
dc.subjectGeneral Environmental Science
dc.subjectStrategy and Management
dc.subjectIndustrial and Manufacturing Engineering
dc.subjectSDG 7 - Affordable and Clean Energy
dc.titleSustainable production of nanoemulsions by membrane-assisted nanoemulsification using novel aroma-based hydrophobic deep eutectic solvents for enhanced antifungal activitiesen
dc.typejournal article
degois.publication.titleJournal of Cleaner Production
degois.publication.volume444
dspace.entity.typePublication
oaire.awardNumberUIDP/04423/2020
oaire.awardNumberUIDB/04462/2020
oaire.awardNumberUIDP/04462/2020
oaire.awardNumberLA/P/0087/2020
oaire.awardNumberSFRH/BD/146967/2019
oaire.awardNumberUIDB/50006/2020
oaire.awardNumberUIDP/50006/2020
oaire.awardTitleInterdisciplinary Centre of Marine and Environmental Research
oaire.awardTitleiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
oaire.awardTitleiNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG e ITQB)
oaire.awardTitleLife Sciences for a Healthy and Sustainable Future
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardTitleAssociated Laboratory for Green Chemistry - Clean Technologies and Processes
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04423%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04462%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04462%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0087%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/OE/SFRH%2FBD%2F146967%2F2019/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F50006%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F50006%2F2020/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStreamOE
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication78a00605-4d0d-4b52-92d6-ebb37e0cdc61
relation.isProjectOfPublication5974b624-6f0c-4e2e-a527-c96f9e4a69a8
relation.isProjectOfPublicationd9074f46-a47d-4907-8f8c-0460a19a39a1
relation.isProjectOfPublicationb73ff267-3225-4ffd-951c-be3f53fca0e0
relation.isProjectOfPublication7fd01a16-12fc-4ad4-aba4-58527470027f
relation.isProjectOfPublicationadc84c24-ba1d-4bcd-b753-2128ce9a5faa
relation.isProjectOfPublication4d9a4d40-4803-4f3a-976b-d6eaaef42510
relation.isProjectOfPublication.latestForDiscoveryd9074f46-a47d-4907-8f8c-0460a19a39a1

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
Sustainable_production_of_nanoemulsions.pdf
Tamanho:
5.34 MB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

Home collection (FCT)