A carregar...
Publicação
Berries driven (poly)phenols-induced cytoprotection in cardiomyocytes
| Nome: | Descrição: | Tamanho: | Formato: | |
|---|---|---|---|---|
| 1.42 MB | Adobe PDF |
Autores
Orientador(es)
Resumo(s)
Cardiovascular diseases (CVDs) are a prominent health problem, being the leading cause of death worldwide. Numerous studies have been focus on the beneficial effects of dietary (poly)phenols, as a way to prevent the onset of CVDs.
Recently, a link between CVDs, metabolism, mitochondria and diet has been evidenced. This link might involve a crosstalk between mitochondria functions, autophagy and cell death and would be regulated at the cellular level by various classes of sensors such as proteins as well as second messengers.
The purpose of this study is to evaluate the potential of novel berries driven (poly)phenols (BDP) metabolites in cardioprotection and unravel the BDP-targeted cytoprotective mechanisms namely in mitochondrial functionality. Therefore studies were conducted using H9c2 cells and neonatal rat cardiomyocytes treated with tert-butyl hydroperoxide or isoproterenol to promote cell death, modeling chronical cardiac diseases.
Analysis of mitochondrial population, in neonatal rat cardiomyocytes and H9c2 cells respectively, showed that BDP metabolites induce an increase of mitochondrial population. Moreover BDP metabolites appear to not protect against cell death induced by isoproterenol activated pathway. An important finding in this work was that BDP metabolites are capable of improving cardiac contractile functions, without decreasing isoproterenol induced cell death.
Although not completely conclusive, the obtained results support a need for future research, as these compounds can be promising therapeutic agents in CVDs prevention fostering an active and healthy ageing. Given the growing number of cardiovascular incidents, being able to possibly develop a prophylactic drug against CVDs, would be a great achievement. Creating a prophylactic drug from BDP metabolites, would help people with a propensity to CVDs keeping a higher quality of life and reduce the need for expensive cardiac treatments.
Descrição
Palavras-chave
Berries driven (poly)phenols cardiovascular diseases mitochondria cardiomyocyte oxidative stress