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Projeto de Engenharia Conceptual de uma unidade de fabrico de produtos farmacêuticos à base de Canábis Medicinal, em Portugal
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A presente dissertação pretende desenvolver um Projeto Conceptual para a implementação de uma unidade de fabrico de produtos farmacêuticos à base de Canábis Medicinal,
em Portugal. Com vista a resolver problemáticas como o número reduzido de unidades farmacêuticas de produção de extratos e isolados de Canábis, a falta de consistência de produtos no mercado e a ausência de produtos inovadores, este projeto perspetiva-se como uma
oportunidade de negócio.
O desenvolvimento do trabalho inicia-se com a análise de mercado que visa justificar
a melhor localização para a implementação e construção da unidade fabril e, posterior cálculo
da capacidade a instalar na fábrica, de forma a alcançar os mercados alvo de Portugal e
Alemanha, assumindo um Market Share de 3,5%. Foi calculada a capacidade anual instalar,
estabelecendo-se 505 kg de canabinóides por ano, vendidos sobre a forma de Isolados de
CBD e Frascos de 300 ml de Nanoemulsão com 10% de CBD.
Quanto ao desenvolvimento do Projeto de Engenharia Conceptual foi adotado o pro-
cesso de extração com CO2 supercrítico. Pela elaboração do balanço mássico ao processo,
o processamento de 25 kg de flor seca por dia, permite a produção de 1,3 kg de Cristais de
CBD e 518 frascos de Nanoemulsões, diariamente.
Finalizado o Projeto de Engenharia, foi calculado o investimento total, que ficará no
valor de 19 Milhões de euros. O estudo conclui que o Projeto Conceptual de Implementação
de uma nova unidade fabril de produção de produtos farmacêuticos à base de Canábis Medicinal tem viabilidade económica, dado que tem uma TIR de 26,63% e um VAL de 31,954,129€
Para complementar o estudo do projeto, sugere-se uma análise de risco às zonas de
risco com classificação ATEX e ao perigo de contaminação cruzada.
This dissertation aims to develop a Conceptual Project for the implementation of a manufacturing unit for pharmaceutical products based on medicinal cannabis in Portugal. With a view to solving problems such as the small number of pharmaceutical units producing can- nabis extracts and isolates, the lack of consistency of products on the market and the absence of innovative products, this project is seen as a business opportunity. The work began with a market analysis aimed at justifying the best location for the implementation and construction of the factory and then calculating the capacity to be installed in the factory in order to reach the target markets of Portugal and Germany, assuming a market share of 3.5%. The annual installed capacity was calculated, establishing 505 kg of canna- binoids per year, sold in the form of CBD Isolates and 300 ml bottles of nanoemulsions with 10% CBD. As for the development of the Conceptual Engineering Project, the supercritical CO2 extraction process was adopted. According to the mass balance of the process, processing 25kg of dried flower per day allows to produce 1.3kg of CBD crystals and 518 bottles of nanoemulsions per day. Once the engineering project has been finalized, the total investment has been calcu- lated, which will amount to 19 million euros. The study concludes that the Conceptual Project for the Implementation of a New Manufacturing Unit for the Production of Medicinal cannabis- based pharmaceutical products is economically viable, given that the IRR is 26,63% and the NPV is 31,954,129€. To complement the project study, a risk analysis of ATEX-classified risk zones and the danger of cross-contamination is suggested.
This dissertation aims to develop a Conceptual Project for the implementation of a manufacturing unit for pharmaceutical products based on medicinal cannabis in Portugal. With a view to solving problems such as the small number of pharmaceutical units producing can- nabis extracts and isolates, the lack of consistency of products on the market and the absence of innovative products, this project is seen as a business opportunity. The work began with a market analysis aimed at justifying the best location for the implementation and construction of the factory and then calculating the capacity to be installed in the factory in order to reach the target markets of Portugal and Germany, assuming a market share of 3.5%. The annual installed capacity was calculated, establishing 505 kg of canna- binoids per year, sold in the form of CBD Isolates and 300 ml bottles of nanoemulsions with 10% CBD. As for the development of the Conceptual Engineering Project, the supercritical CO2 extraction process was adopted. According to the mass balance of the process, processing 25kg of dried flower per day allows to produce 1.3kg of CBD crystals and 518 bottles of nanoemulsions per day. Once the engineering project has been finalized, the total investment has been calcu- lated, which will amount to 19 million euros. The study concludes that the Conceptual Project for the Implementation of a New Manufacturing Unit for the Production of Medicinal cannabis- based pharmaceutical products is economically viable, given that the IRR is 26,63% and the NPV is 31,954,129€. To complement the project study, a risk analysis of ATEX-classified risk zones and the danger of cross-contamination is suggested.
Descrição
Palavras-chave
Canábis medicinal CBD Nanoemulsões Canabinóides Isolados de CBD Unidade Fabril