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An Integrated Approach to the Anti-Inflammatory, Antioxidant, and Genotoxic Potential of Portuguese Traditional Preparations from the Bark of Anacardium occidentale L.

2024-01-31Artigo científico Acesso aberto
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dc.contributor.authorEncarnação, Sofia
dc.contributor.authorLima, Katelene
dc.contributor.authorMalú, Quintino
dc.contributor.authorCaldeira, Gonçalo I.
dc.contributor.authorDuarte, Maria Paula
dc.contributor.authorRocha, João
dc.contributor.authorLima, Beatriz Silva
dc.contributor.authorSilva, Olga
dc.contributor.institutionMEtRICS - Centro de Engenharia Mecânica e Sustentabilidade de Recursos
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2024-09-25T22:26:23Z
dc.date.available2024-09-25T22:26:23Z
dc.date.issued2024-01-31
dc.descriptionFunding Information: This research was funded by Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to iMed.ULisboa (UIDP/04138/2020). Publisher Copyright: © 2024 by the authors.
dc.description.abstractAnacardium occidentale L. stem bark Traditional Herbal Preparations (AoBTHPs) are widely used in traditional medicine to treat inflammatory conditions, such as diabetes. The present study aims to evaluate the anti-inflammatory, antioxidant, and genotoxic potential of red and white Portuguese AoBTHPs. Using a carrageenan-induced rat paw edema model, a significant anti-edema effect was observed for all tested doses of white AoBTHP (40.2, 71.5, and 127.0 mg/kg) and the two highest doses of red AoB THP (71.5 and 127.0 mg/kg). The anti-edema effect of red AoBTHP’s highest dose was much more effective than indomethacin 10 mg/kg, Trolox 30 mg/kg, and Tempol 30 mg/kg. In DPPH, FRAP, and TAC using the phosphomolybdenum method, both types of AoBTHPs showed similar antioxidant activity and no genotoxicity up to 5000 µg/plate in the Ames test. The LC-UV/DAD-ESI/MS fingerprint allowed the identification of gallic and protocatechuic acids as the two main marker compounds and the presence of catechin, epicatechin, epigallocatechin gallate, and ellagic acid in both AoBTHPs. The obtained results support the validation of red and white AoB and their THPs as anti-inflammatory agents and contribute to the possible development of promising new therapeutic options to treat inflammatory conditions.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent18
dc.format.extent1408327
dc.identifier.doi10.3390/plants13030420
dc.identifier.issn2223-7747
dc.identifier.otherPURE: 99740040
dc.identifier.otherPURE UUID: f4e09406-b679-4f11-960a-08479d79859a
dc.identifier.otherScopus: 85184509755
dc.identifier.otherWOS: 001161013800001
dc.identifier.otherPubMed: 38337956
dc.identifier.otherPubMedCentral: PMC10857173
dc.identifier.urihttp://hdl.handle.net/10362/172401
dc.identifier.urlhttps://www.scopus.com/pages/publications/85184509755
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcashew
dc.subjectethnopharmacology
dc.subjectfree radical scavenger
dc.subjectinflammation
dc.subjectphytochemistry
dc.subjectpre-clinical safety
dc.subjectEcology, Evolution, Behavior and Systematics
dc.subjectEcology
dc.subjectPlant Science
dc.subjectSDG 3 - Good Health and Well-being
dc.titleAn Integrated Approach to the Anti-Inflammatory, Antioxidant, and Genotoxic Potential of Portuguese Traditional Preparations from the Bark of Anacardium occidentale L.en
dc.typejournal article
degois.publication.issue3
degois.publication.titlePlants
degois.publication.volume13
dspace.entity.typePublication
rcaap.rightsopenAccess

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