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Cysteine metabolic remodeilng : a metabolic marker for cancer aggressiveness and a noval putative target in oncological management
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Abstract
Cancer remains a major health issue and one of the most frequent causes of death.
The present work explores the central role of cysteine metabolic remodeling, an
often overlooked yet pivotal phenomenon with substantial implications, in the field of
carcinogenesis and cancer response.
The central objective of this thesis was to clarify the intricate role of cysteine
metabolic remodeling in highly prevalent and lethal forms of cancer that lack effective
therapeutic solutions against resistance and advanced disease. Results indicate the
significance of cysteine metabolic rewiring, under the regulatory influence of BRD9
status, in shaping the aggressiveness of cutaneous melanoma (CM) through MST
modulation. Furthermore, this thesis underscores the value of metabolic profiling,
specifically focused on cysteine metabolism, in stratifying patients for tailored therapy in
non-small cell lung cancer (NSCLC) and demonstrates the feasibility of inhibiting
cysteine metabolism as a novel therapeutic avenue for NSCLC, colorectal cancer (CRC),
and breast cancer (BC).
Overall, this work offers prospects for identifying cysteine metabolism as a new
and complex therapeutic target and reveals the hidden potential of cysteine metabolic
remodeling in the intricate landscape of cancer biology.
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Cysteine Metabolic remodeling Cutaneous melanoma Non-small cell lung cancer Breast cancer Cancer therapy