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Optimization of Nanoencapsulation of Codium tomentosum Extract and Its Potential Application in Yogurt Fortification

2025-03-28Artigo científico Acesso aberto
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dc.contributor.authorCosta, Micaela
dc.contributor.authorSoares, Cristina
dc.contributor.authorSilva, Aurora
dc.contributor.authorBarroso, Maria Fátima
dc.contributor.authorSimões, Pedro
dc.contributor.authorFerreira, Mariana
dc.contributor.authorGameiro, Paula
dc.contributor.authorGrosso, Clara
dc.contributor.authorDelerue-Matos, Cristina
dc.contributor.institutionLAQV@REQUIMTE
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-06-23T21:14:08Z
dc.date.available2025-06-23T21:14:08Z
dc.date.issued2025-03-28
dc.descriptionFunding Information: This work was financed by FEDER—Fundo Europeu de Desenvolvimento Regional funds through the COMPETE 2020—Operacional Programme for Competitiveness and Internationalisation (POCI), and by Portuguese funds through FCT—Fundação para a Ciência e a Tecnologia in the framework of the project POCI-01-0145-FEDER-030240—PTDC/OCE-ETA/30240/2017—SilverBrain—From Sea to Brain: Green Neuroprotective Extracts for Nanoencapsulation and Functional Food Production. This work was supported by project UID/50006—Laboratório Associado para a Química Verde—Tecnologias e Processos Limpos, financed by PT national funds (FCT/MECI, Fundação para a Ciência e Tecnologia and Ministério da Educação, Ciência e Inovação). Aurora Silva thanks the EU-FORA Fellowship Program (EUBA-EFSA-2023-ENREL-01) for the grant received. MF thanks FCT and LAQV-REQUIMTE for a post-doc fellowship (REQUIMTE 2019-34). Publisher Copyright: © 2025 by the authors.
dc.description.abstractMarine macroalgae are excellent sources of bioactive compounds recognized by their pharmaceutical and biomedical potential. A subcritical water extraction (SWE) was applied to the macroalga Codium tomentosum, and the extract was used to prepare phytosomes. A Box–Behnken design was applied to optimize the entrapment efficiency. These phytosomes were further modified with DSPE-PEG (2000)-maleimide and apolipoprotein E and characterized by dynamic light scattering, UV spectrophotometry, octanol/water partition coefficient, differential scanning calorimetry, and Fourier transform infrared spectroscopy. As proof of concept, prototypes of functional food tailored to the elderly were produced. Yogurts were fortified with seaweed extract or phytosomes, and physicochemical properties and proximal composition (pH, acidity, syneresis, moisture, peroxides, proteins, total lipids, sugar content, ash, and mineral composition) were analyzed. The antioxidant and the inhibition capacity of two brain enzymes, cholinesterases (AChE and BuChE), involved in the pathogenesis of Alzheimer’s disease, were also evaluated in the final prototypes. Despite their unappealing sensory characteristics, the results are promising for integrating marine extracts with potential neuroprotective effects into functional foods.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent21
dc.format.extent2563363
dc.identifier.doi10.3390/md23040147
dc.identifier.issn1660-3397
dc.identifier.otherPURE: 116476147
dc.identifier.otherPURE UUID: 482c1256-06af-4e83-93a5-98cbc7aa8803
dc.identifier.otherScopus: 105003625397
dc.identifier.otherPubMed: 40278268
dc.identifier.otherWOS: 001475304800001
dc.identifier.otherPubMedCentral: PMC12028962
dc.identifier.urihttp://hdl.handle.net/10362/184350
dc.identifier.urlhttps://www.scopus.com/pages/publications/105003625397
dc.identifier.urlhttps://www.webofscience.com/wos/woscc/full-record/WOS:001475304800001
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FOCE-ETA%2F30240%2F2017/PT
dc.relationDo mar para o cérebro: Extratos verdes neuroprotetores para nanoencapsulamento e produção de alimentos funcionais
dc.subjectBox–Behnken design
dc.subjectFood fortification
dc.subjectPhytosomes
dc.subjectSeaweeds
dc.subjectSubcritical water extraction
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPharmacology, Toxicology and Pharmaceutics (miscellaneous)
dc.subjectSDG 14 - Life Below Water
dc.titleOptimization of Nanoencapsulation of Codium tomentosum Extract and Its Potential Application in Yogurt Fortificationen
dc.typejournal article
degois.publication.firstPage1
degois.publication.issue4
degois.publication.lastPage21
degois.publication.titleMarine Drugs
degois.publication.volume23
dspace.entity.typePublication
oaire.awardNumberPTDC/OCE-ETA/30240/2017
oaire.awardTitleDo mar para o cérebro: Extratos verdes neuroprotetores para nanoencapsulamento e produção de alimentos funcionais
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017/PTDC%2FOCE-ETA%2F30240%2F2017/PT
oaire.fundingStreamConcurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2017
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication8ff03eef-09e1-4fed-a3b7-26b6562ecefb
relation.isProjectOfPublication.latestForDiscovery8ff03eef-09e1-4fed-a3b7-26b6562ecefb

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