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Second and third TNF inhibitors in European patients with axial spondyloarthritis

2024-07Artigo científico Acesso aberto
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dc.contributor.authorLinde, Louise
dc.contributor.authorØrnbjerg, Lykke Midtbøll
dc.contributor.authorBrahe, Cecilie Heegaard
dc.contributor.authorWallman, Johan Karlsson
dc.contributor.authorDi Giuseppe, Daniela
dc.contributor.authorZávada, Jakub
dc.contributor.authorCastrejon, Isabel
dc.contributor.authorDíaz-Gonzalez, Federico
dc.contributor.authorRotar, Ziga
dc.contributor.authorTomšič, Matija
dc.contributor.authorGlintborg, Bente
dc.contributor.authorGudbjornsson, Bjorn
dc.contributor.authorGeirsson, Arni Jon
dc.contributor.authorMichelsen, Brigitte
dc.contributor.authorKristianslund, Eirik Klami
dc.contributor.authorSantos, Maria José
dc.contributor.authorBarcelos, Anabela
dc.contributor.authorNordström, Dan
dc.contributor.authorEklund, Kari K
dc.contributor.authorCiurea, Adrian
dc.contributor.authorNissen, Michael
dc.contributor.authorAkar, Servet
dc.contributor.authorHyldstrup, Lise Hejl
dc.contributor.authorKrogh, Niels Steen
dc.contributor.authorHetland, Merete Lund
dc.contributor.authorØstergaard, Mikkel
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - pólo NMS
dc.contributor.pblBritish Society for Rheumatology | Oxford University Press
dc.date.accessioned2023-11-16T22:09:14Z
dc.date.available2023-11-16T22:09:14Z
dc.date.issued2024-07
dc.description.abstractOBJECTIVE: To investigate real-world effectiveness of tumor necrosis factor inhibitors (TNFi) in patients with axial spondyloarthritis (axSpA) and the association with 1) treatment line (second and third TNFi-series) and 2) reason for withdrawal from the preceding TNFi (lack of efficacy (LOE) versus adverse events (AE)). METHODS: Prospectively collected routine care data from 12 European registries were pooled. Rates for 12-month drug retention and 6-month remission (Ankylosing Spondylitis Disease Activity Score C-reactive protein inactive disease (ASDAS-ID)) were assessed in second and third TNFi-series and stratified by withdrawal reason. RESULTS: We included 8254 s and 2939 third TNFi-series; 12-month drug retention rates were similar (71%). Six-month ASDAS-ID rates were higher for the second (23%) than third TNFi (16%). Twelve-month drug retention rates for patients withdrawing from the preceding TNFi due to AE versus LOE were similar for the second (68% and 67%) and third TNFi (both 68%), while for the second TNFi, rates were lower in primary than secondary non-responders (LOE < 26 versus ≥26 weeks) (58% versus 71%, p< 0.001). Six-month ASDAS-ID rates for the second TNFi were higher if the withdrawal reason was AE (27%) versus LOE (17%), p< 0.001, while similar for the third TNFi (19% versus 13%, p= 0.20). CONCLUSION: A similar proportion of axSpA patients remained on a second and third TNFi after one year, but with low remission rates for the third TNFi. Remission rates on the second TNFi (but not the third) were higher if the withdrawal reason from the preceding TNFi was AE versus LOE.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1063209
dc.identifier.doi10.1093/rheumatology/kead494
dc.identifier.issn1462-0332
dc.identifier.otherPURE: 74232043
dc.identifier.otherPURE UUID: 33c5ca4f-f638-49fa-b29d-53443f40efe1
dc.identifier.otherPubMed: 37738257
dc.identifier.otherScopus: 85197586238
dc.identifier.urihttp://hdl.handle.net/10362/160037
dc.language.isoeng
dc.peerreviewedyes
dc.subjectAxial spondyloarthritis
dc.subjectadverse events
dc.subjecteffectiveness
dc.subjectack of efficacy
dc.subjectswitching TNF-inhibitors
dc.titleSecond and third TNF inhibitors in European patients with axial spondyloarthritisen
dc.title.subtitleEffectiveness and impact of the reason for switchingen
dc.typejournal article
degois.publication.firstPage1882
degois.publication.issue7
degois.publication.lastPage1892
degois.publication.titleRheumatology
degois.publication.volume63
dspace.entity.typePublication
rcaap.rightsopenAccess

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