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Resumo(s)
The question how protein function evolves is a fundamental problem
with profound implications for both functional end evolutionary
studies on proteins. Here, we review some of the work that has addressed
or contributed to this question. We identify and comment
on three different levels relevant for the evolution of protein function.
First, biochemistry. This is the focus of our discussion, as
protein function itself commonly receives least attention in studies
on protein evolution.(...)
Descrição
Dissertation presented to obtain the PhD degree in Computational Biology.
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Universidade Nova de Lisboa. Instituto de Tecnologia Química e Biológica.
