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Uncovering the burden of Influenza in children in Portugal, 2008–2018

2024-01-18Artigo científico Acesso aberto
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dc.contributor.authorCaldas Afonso, Alberto
dc.contributor.authorGouveia, Catarina
dc.contributor.authorJanuário, Gustavo
dc.contributor.authorCarmo, Mafalda
dc.contributor.authorLopes, Hugo
dc.contributor.authorBricout, Hélène
dc.contributor.authorGomes, Catarina
dc.contributor.authorFroes, Filipe
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.institutionEscola Nacional de Saúde Pública (ENSP)
dc.contributor.institutionCentro de Investigação em Saúde Pública (CISP/PHRC)
dc.contributor.institutionComprehensive Health Research Centre (CHRC) - Pólo ENSP
dc.contributor.pblSpringer Verlag
dc.date.accessioned2024-01-31T23:35:56Z
dc.date.available2024-01-31T23:35:56Z
dc.date.issued2024-01-18
dc.descriptionFunding Information: The BARI study was funded by Sanofi. Publisher Copyright: © 2024, The Author(s).
dc.description.abstractBackground: Despite their higher risk of developing severe disease, little is known about the burden of influenza in Portugal in children aged < 5 years old. This study aims to cover this gap by estimating the clinical and economic burden of severe influenza in children, in Portugal, during ten consecutive influenza seasons (2008/09-2017/18). Methods: We reviewed hospitalizations in children aged < 5 years old using anonymized administrative data covering all public hospitals discharges in mainland Portugal. The burden of hospitalization and in-hospital mortality directly coded as due to influenza was supplemented by the indirect burden calculated from excess hospitalization and mortality (influenza-associated), estimated for four groups of diagnoses (pneumonia or influenza, respiratory, respiratory or cardiovascular, and all-cause), through cyclic regression models integrating the incidence of influenza. Means were reported excluding the H1N1pdm09 pandemic (2009/10). Results: The mean annual number of hospitalizations coded as due to influenza was 189 (41.3 cases per 100,000 children aged < 5 years old). Hospitalization rates decreased with increasing age. Nine-in-ten children were previously healthy, but the presence of comorbidities increased with age. Children stayed, on average, 6.1 days at the hospital. Invasive mechanical ventilation was used in 2.4% of hospitalizations and non-invasive in 3.1%. Influenza-associated excess hospitalizations between 2008 and 2018 were estimated at 1,850 in pneumonia or influenza, 1,760 in respiratory, 1,787 in respiratory or cardiovascular, and 1,879 in all-cause models. A total of 95 influenza-associated excess deaths were estimated in all-cause, 14 in respiratory or cardiovascular, and 9 in respiratory models. Over ten years, influenza hospitalizations were estimated to have cost the National Health Service at least €2.9 million, of which 66.5% from healthy children. Conclusions: Influenza viruses led to a high number of hospitalizations in children. Most were previously healthy. Results should lead to a reflection on the adequate preventive measures to protect this age group.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent1767547
dc.identifier.doi10.1186/s12879-023-08685-z
dc.identifier.issn2374-4235
dc.identifier.otherPURE: 82425270
dc.identifier.otherPURE UUID: 5758a535-e03c-45d1-93d4-1290751e422f
dc.identifier.otherScopus: 85182665447
dc.identifier.otherPubMed: 38238649
dc.identifier.urihttp://hdl.handle.net/10362/162977
dc.identifier.urlhttps://www.scopus.com/pages/publications/85182665447
dc.language.isoeng
dc.peerreviewedyes
dc.subjectBurden
dc.subjectChildren
dc.subjectExcess
dc.subjectHealthy
dc.subjectHospitalization
dc.subjectInfluenza
dc.subjectMortality
dc.subjectPortugal
dc.subjectInfectious Diseases
dc.subjectSDG 3 - Good Health and Well-being
dc.titleUncovering the burden of Influenza in children in Portugal, 2008–2018en
dc.typejournal article
degois.publication.issue1
degois.publication.titleBMC Infectious Diseases
degois.publication.volume24
dspace.entity.typePublication
rcaap.rightsopenAccess

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