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Acidic deep eutectic systems and their capacity to increase drug bioavailability
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Resumo(s)
The pharmaceutical industry faces several challenges concerning the bioavailability of novel medications mainly because of their limited permeability and/or solubility. These are two crucial features that influence how well a medication is absorbed. The biopharmaceutics categorization system is a crucial instrument for the classification of active pharmaceutical ingredients (API) based on their permeability and solubility. In this work we explored the possibility of deep eutectic systems (DES) to be used as solubility and permeability enhancers of four different drugs supplied by Boeringher Ingelheim. In this investigation, the API's were dissolved in various DES and their solubility measured in PBS at 37 °C. Our findings suggest that CA: Gly: W (1:1:1) was able to increase the solubility of all four drugs in PBS, as well as their permeability. In summary, BI0001 and BI0002 following pre-solubilization in that system drugs shifted from class III to from class I included, whereas BI0005 still kept its class III classification although having higher solubility and permeability. The encouraging outcomes highlight DES's potential as a technique to boost drug's bioavailability.
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Funding Information:
This project has received funding from the European Union's Horizon 2020 (European Research Council) under grant agreement No ERC-2016-CoG 725,034. This work was also supported by the Associate Laboratory for Green Chemistry – LAQV – which is financed by national funds from FCT/MCTES (UIDP/50006/2020).
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© 2025
Palavras-chave
Bioavailability Biopharmaceutical classification system (BCS) Deep eutectic system (DES) Drug permeability Drug solubility General Chemical Engineering General Physics and Astronomy Physical and Theoretical Chemistry