Logo do repositório
 
Publicação

Dietary Oleic Acid and SCD16 and ELOVL6 Estimated Activities Can Modify Erythrocyte Membrane n-3 and n-6 HUFA Partition

2025-02Artigo científico Acesso aberto
Ver registo simples
dc.contributor.authorBispo, Paulo
dc.contributor.authorRodrigues, Pedro O.
dc.contributor.authorBandarra, Narcisa M.
dc.contributor.institutionNOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2025-04-10T15:59:56Z
dc.date.available2025-04-10T15:59:56Z
dc.date.issued2025-02
dc.descriptionFunding Information: The present study was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT) through the grant PTDC-SAU/OSM/2006/70560 (principal investigator: P.O.R.). Publisher Copyright: © 2025 by the authors.
dc.description.abstractIn this work, we studied the relationships between the most representative fatty acids (FAs) and their ratios in red blood cell (RBC) membranes and dietary fatty acids alongside several cardiometabolic risk factors. Twenty-six individuals were enrolled with a mean age of 50.4 ± 12.7 years (16 males and 10 females). By bivariate analysis, dietary oleic acid (OA) correlated negatively with C20:4n-6 (AA) (p = 0.031) in RBCs. With multivariate regression analysis, dietary OA (p < 0.001) is an independent predictor and negatively associated with AA levels in RBCs, while the elongation of very-long-chain fatty acids 6 (ELOVL6) and stearoyl-CoA desaturase 16 (SCD16) activities (p < 0.05) was positively associated with AA levels in RBCs. The multivariate regression models also showed that dietary OA was an independent predictor and positively associated with C22:5n-3 (DPA) in RBCs. Furthermore, BMI positively correlated with SCD16, and both SCD16 and SCD18 were positively associated with triacylglycerols levels. In addition, SCD16 positively and significantly correlated with LDL-c and the LDL-c/HDL-c ratio and negatively correlated with the ApoA1/ApoB ratio, and SCD16 and ELOVL6 were significantly associated with HDL molecular subfractions. Therefore, our data underline that OA, SCD16 and ELOVL6 can interfere with n-3 and n-6 partition in biomembranes such as RBCs, suggesting an important molecular (patho)physiological regulatory mechanism role in controlling bioactive molecules’ availability such as those involved in the immune-inflammatory response.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent284944
dc.identifier.doi10.3390/cimb47020081
dc.identifier.issn1467-3037
dc.identifier.otherPURE: 114110135
dc.identifier.otherPURE UUID: 534baad6-6155-4285-949a-14b75f500d6c
dc.identifier.otherScopus: 85218891322
dc.identifier.urihttp://hdl.handle.net/10362/182066
dc.identifier.urlhttps://www.scopus.com/pages/publications/85218891322
dc.language.isoeng
dc.peerreviewedyes
dc.subjectcardiometabolic biomarkers
dc.subjectdietary oleic acid
dc.subjectmetabolism
dc.subjectn-6/n-3 HUFA
dc.subjectred blood cells
dc.subjectMicrobiology
dc.subjectMolecular Biology
dc.subjectMicrobiology (medical)
dc.titleDietary Oleic Acid and SCD16 and ELOVL6 Estimated Activities Can Modify Erythrocyte Membrane n-3 and n-6 HUFA Partitionen
dc.title.subtitleA Pilot Studyen
dc.typejournal article
degois.publication.issue2
degois.publication.titleCurrent issues in molecular biology
degois.publication.volume47
dspace.entity.typePublication
rcaap.rightsopenAccess

Ficheiros

Principais
A mostrar 1 - 1 de 1
Miniatura
Nome:
cimb-47-00081.pdf
Tamanho:
278.27 KB
Formato:
Adobe Portable Document Format
Ver/Abrir

Coleções

NMS - Artigos em revista internacional com arbitragem científica