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Effect of Graphene vs. Reduced Graphene Oxide in Gold Nanoparticles for Optical Biosensors

2022-03-04Artigo científico Acesso aberto
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dc.contributor.authorCarvalho, Ana P. G.
dc.contributor.authorAlegria, Elisabete C. B. A.
dc.contributor.authorFantoni, Alessandro
dc.contributor.authorFerraria, Ana M.
dc.contributor.authorDo Rego, Ana M. Botelho
dc.contributor.authorRibeiro, Ana P. C.
dc.contributor.institutionCTS - Centro de Tecnologia e Sistemas
dc.contributor.institutionUNINOVA-Instituto de Desenvolvimento de Novas Tecnologias
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-10-05T22:15:50Z
dc.date.available2022-10-05T22:15:50Z
dc.date.issued2022-03-04
dc.descriptionThis research was funded by EU funds through the FEDER European Regional Development Fund (project LISBOA-02-0145-FEDER-031311) project LA/P/0056/2020 of Institute of Molecular Sciences, and LA/P/0140/2020 of i4HB, project UID/EEA/00066/2020 from the Center of Technology and Systems, and from the Instituto Politécnico de Lisboa with IPL/2018/STREAM_ISEL and IPL/2020/AGE-SPReS_ISEL projects. APCR and AMF thank the Instituto Superior Técnico for the scientific employment contracts IST-ID/119/2018 and IST-ID/131/2018, respectively. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
dc.description.abstractAiming to develop a nanoparticle-based optical biosensor using gold nanoparticles (AuNPs) synthesized using green methods and supported by carbon-based nanomaterials, we studied the role of carbon derivatives in promoting AuNPs localized surface plasmon resonance (LSPR), as well as their morphology, dispersion, and stability. Carbon derivatives are expected to work as immobi-lization platforms for AuNPs, improving their analytical performance. Gold nanoparticles (AuNPs) were prepared using an eco-friendly approach in a single step by reduction of HAuCl4·3H2O using phytochemicals (from tea) which act as both reducing and capping agents. UV–Vis spectroscopy, transmission electron microscopy (TEM), zeta potential (ζ-potential), and X-ray photoelectron spectroscopy (XPS) were used to characterize the AuNPs and nanocomposites. The addition of reduced graphene oxide (rGO) resulted in greater dispersion of AuNPs on the rGO surface compared with carbon-based nanomaterials used as a support. Differences in morphology due to the nature of the carbon support were observed and are discussed here. AuNPs/rGO seem to be the most promising candidates for the development of LSPR biosensors among the three composites we studied (AuNPs/G, AuNPs/GO, and AuNPs/rGO). Simulations based on the Mie scattering theory have been used to outline the effect of the phytochemicals on LSPR, showing that when the presence of the residuals is limited to the formation of a thin capping layer, the quality of the plasmonic resonance is not affected. A further discussion of the application framework is presented.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent20
dc.format.extent38889463
dc.identifier.doi10.3390/bios12030163
dc.identifier.issn2079-6374
dc.identifier.otherPURE: 46292687
dc.identifier.otherPURE UUID: 3139d5d5-40e2-427a-b1c8-0aed6f449aed
dc.identifier.otherScopus: 85126644894
dc.identifier.otherPubMed: 35323433
dc.identifier.otherWOS: 000776154000001
dc.identifier.otherPubMedCentral: PMC8946507
dc.identifier.urihttp://hdl.handle.net/10362/144485
dc.identifier.urlhttps://www.scopus.com/pages/publications/85126644894
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/9471 - RIDTI/PTDC%2FNAN-OPT%2F31311%2F2017/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QIN%2F29778%2F2017/PT
dc.relationStraightforward Synthesis of Multifunctional core-shell composites and their applications
dc.relationCentro de Química Estrutural
dc.relationInstitute for Bioengineering and Biosciences
dc.relationInstitute for Bioengineering and Biosciences
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
dc.subjectAuNPs
dc.subjectBiosensors
dc.subjectMetal–graphene hybrid
dc.subjectMie theory
dc.subjectSimulations
dc.subjectAnalytical Chemistry
dc.subjectBiotechnology
dc.subjectBiomedical Engineering
dc.subjectInstrumentation
dc.subjectEngineering (miscellaneous)
dc.subjectClinical Biochemistry
dc.titleEffect of Graphene vs. Reduced Graphene Oxide in Gold Nanoparticles for Optical Biosensorsen
dc.title.subtitleA Comparative Studyen
dc.typejournal article
degois.publication.issue3
degois.publication.titleBiosensors
degois.publication.volume12
dspace.entity.typePublication
oaire.awardNumberPTDC/QUI-QIN/29778/2017
oaire.awardNumberUIDB/00100/2020
oaire.awardNumberUIDB/04565/2020
oaire.awardNumberUIDP/04565/2020
oaire.awardTitleStraightforward Synthesis of Multifunctional core-shell composites and their applications
oaire.awardTitleCentro de Química Estrutural
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FQUI-QIN%2F29778%2F2017/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F00100%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04565%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04565%2F2020/PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
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project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
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