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Muscle glycome in idiopathic inflammatory myopathies

2023-07-21Artigo científico Acesso aberto
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dc.contributor.authorCampar, Ana
dc.contributor.authorAlves, Inês
dc.contributor.authorSantos-Pereira, Beatriz
dc.contributor.authorNogueira, Rafaela
dc.contributor.authorPinto, Miguel Mendonça
dc.contributor.authorVasconcelos, Carlos
dc.contributor.authorPinho, Salomé S.
dc.contributor.institutionDQ - Departamento de Química
dc.contributor.pblElsevier
dc.date.accessioned2023-12-15T22:46:44Z
dc.date.available2023-12-15T22:46:44Z
dc.date.issued2023-07-21
dc.descriptionFunding: Supported by the Portugal 2020 Partnership Agreement’s Norte Portugal Regional Programme (NORTE 2020) (project NORTE-01-0145-FEDER-000029 ), Fundo Europeu de Desenvolvimento Regional (FEDER) funds from the Compete2020 Science, Technology, and Innovation Operational Programme (POCI), and the Portuguese Foundation for Science and Technology (FCT) (projects POCI-01/0145-FEDER-016601 and POCI-01-0145-FEDER-028772 ). A.C. work was supported by the Portuguese Society of Internal Medicine’s Group for Study of Autoimmune Diseases ( NEDAI ). I.A. and S.S.P. were also funded by Clinical Research in Autoimmunity prize (supported by National Medical Association in Autoimmunity (NEDAI) and National Society of Internal Medicine (SPMI)) and Pfizer prize (supported by Pfizer and Society of Medical Sciences of Lisbon ). Publisher Copyright: © 2023 The Author(s)
dc.description.abstractIdiopathic inflammatory myopathies (IIM) are a group of chronic autoimmune diseases mainly affecting proximal muscles. Absence of meaningful prognostic factors in IIM has hindered new therapies development. Glycans are essential molecules that regulate immunological tolerance and consequently the onset of autoreactive immune response. We showed that muscle biopsies from patients with IIM revealed a deficiency in the glycosylation pathway resulting in loss of branched N-glycans. At diagnosis, this glycosignature predicted disease relapse and treatment refractoriness. Peripheral CD4+ T cells from active-disease patients shown a deficiency in branched N-glycans, linked to increased IL-6 production. Glycan supplementation, restoring homeostatic glycosylation profile, led to a decrease in IL-6 levels. This study highlights the biological and clinical importance of glycosylation in IIM immunopathogenesis, providing a potential mechanism for IL-6 production. This pinpoints muscle glycome as promising biomarker for personalized follow-up and a potential target for new therapies in a patients’ subgroup with an ominous evolution.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent17
dc.format.extent3372462
dc.identifier.doi10.1016/j.isci.2023.107172
dc.identifier.issn2589-0042
dc.identifier.otherPURE: 75760399
dc.identifier.otherPURE UUID: 7fd43605-b42e-45ba-96f4-241f79e23b09
dc.identifier.otherScopus: 85163854746
dc.identifier.otherWOS: 001056455200001
dc.identifier.otherPubMed: 37404372
dc.identifier.otherPubMedCentral: PMC10316658
dc.identifier.urihttp://hdl.handle.net/10362/161343
dc.identifier.urlhttps://www.scopus.com/pages/publications/85163854746
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/CEEC IND5ed/2022.00337.CEECIND%2FCP1735%2FCT0014/PT
dc.subjectDisease
dc.subjectGlycobiology
dc.subjectGlycomics
dc.subjectHealth sciences
dc.subjectGeneral
dc.titleMuscle glycome in idiopathic inflammatory myopathiesen
dc.title.subtitleImpact in IL-6 production and disease prognosisen
dc.typejournal article
degois.publication.issue7
degois.publication.titleISCIENCE
degois.publication.volume26
dspace.entity.typePublication
rcaap.rightsopenAccess

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