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Profiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agents

2018-04-27Artigo científico Acesso aberto
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dc.contributor.authorGomes, Nelson G. M.
dc.contributor.authorFernandes, Fátima
dc.contributor.authorMadureira-Carvalho, Áurea
dc.contributor.authorValentão, Patrícia
dc.contributor.authorLobo-da-Cunha, Alexandre
dc.contributor.authorCalado, Gonçalo
dc.contributor.authorAndrade, Paula B.
dc.contributor.institutionMARE - Centro de Ciências do Mar e do Ambiente
dc.contributor.institutionDCEA - Departamento de Ciências e Engenharia do Ambiente
dc.contributor.pblMDPI - Multidisciplinary Digital Publishing Institute
dc.date.accessioned2022-12-16T22:07:45Z
dc.date.available2022-12-16T22:07:45Z
dc.date.issued2018-04-27
dc.descriptionproject NORTE-01-0145-FEDER-000024. SFRH/BPD/98732/2013.
dc.description.abstractBioprospection of marine invertebrates has been predominantly biased by the biological richness of tropical regions, thus neglecting macro-organisms from temperate ecosystems. Species that were not the object of studies on their biochemical composition include the Heterobranchia gastropods Armina maculata, Armina tigrina and Aglaja tricolorata, inhabitants of the Portuguese Atlantic coastal waters. Here, we present for the first time the fatty acid profile of neutral lipids and homarine content of these three species. Qualitative and quantitative differences in the fatty acid content among species points to the existence of a fatty acid profile of neutral lipids, particularly of each genus. The results from cytotoxicity assays, using the acetonic extracts of the gastropods on human gastric adenocarcinoma (AGS) and human lung adenocarcinoma (A549) cell lines, revealed a pronounced cytotoxic effect of the A. tigrina extract on both cell lines (IC50 values of 68.75 and 69.77 µg mL− 1 for AGS and A549, respectively). It is worth noting the significant reduction of NO levels in LPS-challenged RAW 264.7 macrophages exposed to A. tricolorata extract, at concentrations as low as 125 µg mL− 1.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent15
dc.format.extent2090724
dc.identifier.doi10.3390/molecules23051027
dc.identifier.otherPURE: 13586339
dc.identifier.otherPURE UUID: 509a6c95-7996-4a11-8ca5-d65d05e2df64
dc.identifier.otherScopus: 85046084910
dc.identifier.otherPubMed: 29702573
dc.identifier.otherPubMedCentral: PMC6100031
dc.identifier.otherWOS: 000435204000042
dc.identifier.urihttp://hdl.handle.net/10362/146320
dc.identifier.urlhttps://www.scopus.com/pages/publications/85046084910
dc.language.isoeng
dc.peerreviewedyes
dc.relationinfo:eu-repo/grantAgreement/FCT/5876/147218/PT
dc.subjectAglaja tricolorata
dc.subjectArmina spp.
dc.subjectDHA
dc.subjectEPA
dc.subjectFatty acids
dc.subjectHomarine
dc.subjectPUFA
dc.subjectSea slugs
dc.subjectAnalytical Chemistry
dc.subjectChemistry (miscellaneous)
dc.subjectMolecular Medicine
dc.subjectPharmaceutical Science
dc.subjectDrug Discovery
dc.subjectPhysical and Theoretical Chemistry
dc.subjectOrganic Chemistry
dc.subjectSDG 3 - Good Health and Well-being
dc.subjectSDG 14 - Life Below Water
dc.titleProfiling of Heterobranchia Sea Slugs from Portuguese Coastal Waters as Producers of Anti-Cancer and Anti-Inflammatory Agentsen
dc.typejournal article
degois.publication.issue5
degois.publication.titleMolecules
degois.publication.volume23
dspace.entity.typePublication
oaire.awardNumberUID/QUI/50006/2013
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/5876/UID%2FQUI%2F50006%2F2013/PT
oaire.fundingStream5876
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublicationb46f8ec0-8992-489c-89d9-54c4a065dc4a
relation.isProjectOfPublication.latestForDiscoveryb46f8ec0-8992-489c-89d9-54c4a065dc4a

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