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In Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexes

2023-07-13Artigo científico Acesso aberto
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dc.contributor.authorChoroba, Katarzyna
dc.contributor.authorFilipe, Beatriz
dc.contributor.authorŚwitlicka, Anna
dc.contributor.authorPenkala, Mateusz
dc.contributor.authorMachura, Barbara
dc.contributor.authorBieńko, Alina
dc.contributor.authorCordeiro, Sandra
dc.contributor.authorBaptista, Pedro V.
dc.contributor.authorFernandes, Alexandra R.
dc.contributor.institutionDCV - Departamento de Ciências da Vida
dc.contributor.institutionUCIBIO - Applied Molecular Biosciences Unit
dc.contributor.pblACS - American Chemical Society
dc.date.accessioned2023-11-20T22:10:52Z
dc.date.available2023-11-20T22:10:52Z
dc.date.issued2023-07-13
dc.descriptionfunds granted under the Research Excellence Initiative of the University of Silesia in Katowice. The authors thank Dr inż. Mariola Siwy for measurements of elemental analysis. Publisher Copyright: © 2023 The Authors. Published by American Chemical Society.
dc.description.abstractThe work is focused on anticancer properties of dipicolinate (dipic)-based vanadium(IV) complexes [VO(dipic)(N∩N)] bearing different diimines (2-(1H-imidazol-2-yl)pyridine, 2-(2-pyridyl)benzimidazole, 1,10-phenanthroline-5,6-dione, 1,10-phenanthroline, and 2,2′-bipyridine), as well as differently 4,7-substituted 1,10-phenanthrolines. The antiproliferative effect of V(IV) systems was analyzed in different tumors (A2780, HCT116, and HCT116-DoxR) and normal (primary human dermal fibroblasts) cell lines, revealing a high cytotoxic effect of [VO(dipic)(N∩N)] with 4,7-dimethoxy-phen (5), 4,7-diphenyl-phen (6), and 1,10-phenanthroline (8) against HCT116-DoxR cells. The cytotoxicity differences between these complexes can be correlated with their different internalization by HCT116-DoxR cells. Worthy of note, these three complexes were found to (i) induce cell death through apoptosis and autophagy pathways, namely, through ROS production; (ii) not to be cytostatic; (iii) to interact with the BSA protein; (iv) do not promote tumor cell migration or a pro-angiogenic capability; (v) show a slight in vivo anti-angiogenic capability, and (vi) do not show in vivo toxicity in a chicken embryo.en
dc.description.versionpublishersversion
dc.description.versionpublished
dc.format.extent20
dc.format.extent5240679
dc.identifier.doi10.1021/acs.jmedchem.3c00255
dc.identifier.issn0022-2623
dc.identifier.otherPURE: 75590433
dc.identifier.otherPURE UUID: c29e8b46-720b-4d9c-885b-e7368d55fad3
dc.identifier.otherScopus: 85163606203
dc.identifier.otherWOS: 001008566000001
dc.identifier.otherPubMed: 37311060
dc.identifier.otherPubMedCentral: PMC10350923
dc.identifier.otherORCID: /0000-0001-5255-7095/work/151383883
dc.identifier.otherORCID: /0000-0003-2054-4438/work/151392211
dc.identifier.urihttp://hdl.handle.net/10362/160196
dc.identifier.urlhttps://www.scopus.com/pages/publications/85163606203
dc.language.isoeng
dc.peerreviewedyes
dc.relationFunding Information: info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/LA%2FP%2F0140%2F2020/PT
dc.relationinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
dc.relationApplied Molecular Biosciences Unit
dc.relationApplied Molecular Biosciences Unit
dc.relationGold4TME: Modulation of tumor microenvironment via combinatorial gold nanomedicines
dc.subjectMolecular Medicine
dc.subjectDrug Discovery
dc.subjectSDG 3 - Good Health and Well-being
dc.titleIn Vitro and In Vivo Biological Activities of Dipicolinate Oxovanadium(IV) Complexesen
dc.typejournal article
degois.publication.firstPage8580
degois.publication.issue13
degois.publication.lastPage8599
degois.publication.titleJournal Of Medicinal Chemistry
degois.publication.volume66
dspace.entity.typePublication
oaire.awardNumberUIDP/04378/2020
oaire.awardNumberUIDB/04378/2020
oaire.awardNumber2021.08629.BD
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleApplied Molecular Biosciences Unit
oaire.awardTitleGold4TME: Modulation of tumor microenvironment via combinatorial gold nanomedicines
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDP%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04378%2F2020/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//2021.08629.BD/PT
oaire.fundingStream6817 - DCRRNI ID
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccess
relation.isProjectOfPublication38373452-5c9c-4724-8def-f03314ecce0e
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relation.isProjectOfPublication.latestForDiscovery1aaaa798-e247-4ecb-8d57-df63a50f5407

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